Atherosclerosis risk factors in systemic lupus erythematosus
| Autor: | Surabhi Agarwal, Jennifer R. Elliott, Susan Manzi |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Inflammation
medicine.medical_specialty business.industry Disease Atherosclerosis medicine.disease Rheumatology Disease activity Pathogenesis Risk Factors Internal medicine Immunology Atheromatous Plaques medicine Humans Lupus Erythematosus Systemic In patient Endothelial dysfunction medicine.symptom skin and connective tissue diseases business |
| Zdroj: | Current Rheumatology Reports. 11:241-247 |
| ISSN: | 1534-6307 1523-3774 |
| Popis: | Cardiovascular disease (CVD) has emerged as a leading cause of morbidity and mortality in patients with systemic lupus erythematosus (SLE). Growing evidence suggests that inflammation plays a key role in the pathogenesis of atherosclerosis from initial endothelial dysfunction to rupture of atheromatous plaques. The increased frequency of atherosclerosis in SLE is likely due to a complex interplay among traditional risk factors, disease-related factors such as medications and disease activity, and inflammatory and immunogenic factors. Identification of these novel risk factors will lead to a better understanding of CVD pathogenesis and may also provide targets for potential treatment strategies. When caring for SLE patients, clinicians should be aware of the increased CVD risk and treat the known modifiable risk factors in addition to controlling disease activity and inflammation. |
| Databáze: | OpenAIRE |
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