The relationships between the availability ofL-tryptophan to the brain, the spontaneous HPA-axis activity, and the HPA-axis responses to dexamethasone in depressed patients
| Autor: | E. Suy, M. Maes, B. Minner |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
endocrine system
medicine.medical_specialty Cortisol awakening response business.industry Urinary system Organic Chemistry Clinical Biochemistry Tryptophan Urine Biochemistry Excretion Endocrinology Internal medicine medicine business Cortisol level hormones hormone substitutes and hormone antagonists Dexamethasone medicine.drug |
| Zdroj: | Amino Acids. 1:57-65 |
| ISSN: | 1438-2199 0939-4451 |
| DOI: | 10.1007/bf00808091 |
| Popis: | The present study was conducted in order to investigate the negative relationships between measures of hypothalamic-pituitary-adrenal (HPA)-axis activity and the availability of L-tryptophan (L-TRP) to the brain in depressive patients. To this end we measured the following: plasma total L-TRP, the ratio of L-TRP to the sum of competing amino acids (CAA), free urinary cortisol (UFC) excretion in 24 hr urine samples, and the 8 a.m. postdexamethasone cortisol levels. We found that the availability of L-TRP to the brain was significantly negatively correlated with the postdexamethasone cortisol values. Cortisol nonsuppressors averaged significantly lower L-TRP and L-TRP/CAA values compared to suppressors. No significant relationship was established between the availability of L-TRP and UFC excretion. It is concluded that the availability of L-TRP is related to the actual alterations in cortisol induced by dexamethasone rather than with the spontaneous baseline HPA-axis activity. |
| Databáze: | OpenAIRE |
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