In vivo effects of Faizol Ubat Batuk, a herbal product on aminopyrine metabolism in rat hepatocytes
| Autor: | Yousef A. Taher, Abas Hj Hussin |
|---|---|
| Přispěvatelé: | AL Fateh University, Tripoli Libya |
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Drug
media_common.quotation_subject Analgesic herbal products lcsh:Medicine Pharmacology In vivo Diabetes mellitus medicine gender media_common Drug metabolism hepatocytes diabetes mellitus business.industry lcsh:R General Medicine Metabolism medicine.disease Streptozotocin drug metabolism Original Article business Perfusion medicine.drug |
| Zdroj: | Libyan Journal of Medicine, Vol 6, Iss 0, Pp 1-5 (2011) Libyan Journal of Medicine; Vol 6 (2011) incl Supplements The Libyan Journal of Medicine Libyan Journal of Medicine; Vol 6, No 1 (2011) |
| ISSN: | 1819-6357 1993-2820 |
| Popis: | Traditional medicines, in particular herbal products, have been used abundantly over the years in curing several diseases. Pharmacological interactions of herbal products with modern drugs, however, remain to some extent unknown. Herein, we examined whether co-administration of Faizol Ubat Batuk (FUB), a mixture of aqueous extract of different plants, modifies the metabolism of aminopyrine, a conventional analgesic drug, in rat liver. We used rat hepatocytes outfitted by collagenase perfusion technique. Determination of aminopyrine n-demethylase activity was performed using the Nash colorimetric method, by measuring the amount of formaldehyde produced. Compared to control treatment, FUB significantly increased the hepatic metabolism of aminopyrine in healthy adult male rats. In contrast, the hepatic metabolism of aminopyrine in adult female rats was decreased. Besides, a biphasic effect in n-demethylase activity was observed in young male rats treated with FUB. In a subsequent experiment, FUB did not change the metabolism of aminopyrine in streptozotocin (STZ)-diabetic adult male rats. In conclusion, administration of FUB could affect phase I aminopyrine metabolism in rat heptocytes. In addition, the effects of FUB on hepatic n-demethylase activity were gender and disease dependent. Keywords: drug metabolism; hepatocytes; herbal products; gender; diabetes mellitus (Published: 28 September 2011) Citation: Libyan J Med 2011, 6 : 5439 - DOI: 10.3402/ljm.v6i0.5439 |
| Databáze: | OpenAIRE |
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