Lipid profile and statin use in critical care setting: implications for kidney outcome
| Autor: | Roberto Narciso, Maria Aparecida Dalboni, Julio Cesar Martins Monte, Beata Marie Redublo Quinto, Marcelino Souza Durão Junior, Oscar Fernando Pavão dos Santos, Isabelle Malbouisson, Marcelo Costa Batista |
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| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_treatment lcsh:Medicine Hydroxymethylglutaryl-CoA reductase inhibitors law.invention Inibidores de hidroximetilglutaril-CoA redutases 0302 clinical medicine Reference Values Risk Factors law Prospective Studies 030212 general & internal medicine Young adult Prospective cohort study APACHE Aged 80 and over Intensive care units General Medicine Acute Kidney Injury Middle Aged Intensive care unit Cholesterol Treatment Outcome Creatinine 030220 oncology & carcinogenesis Mortalidade Original Article Female Adult medicine.medical_specialty Adolescent Critical Care Lower risk C-reactive protein Sepsis Young Adult 03 medical and health sciences Internal medicine medicine Humans Renal replacement therapy Mortality Triglycerides Aged Mechanical ventilation Terapia de substituição renal business.industry lcsh:R Cholesterol HDL Reproducibility of Results Proteína C-reativa Cholesterol LDL Length of Stay medicine.disease Unidades de terapia intensiva ROC Curve business Body mass index |
| Zdroj: | Einstein einstein (São Paulo) v.17 n.3 2019 Einstein (São Paulo) Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE) instacron:IIEPAE Einstein (São Paulo), Vol 17, Iss 3 |
| ISSN: | 2317-6385 1679-4508 |
| Popis: | Objective: To determine whether pre-hospital statin use is associated with lower renal replacement therapy requirement and/or death during intensive care unit stay. Methods: Prospective cohort analysis. We analyzed 670 patients consecutively admitted to the intensive care unit of an academic tertiary-care hospital. Patients with ages ranging from 18 to 80 years admitted to the intensive care unit within the last 48 hours were included in the study. Results: Mean age was 66±16.1 years old, mean body mass index 26.6±4/9kg/m2 and mean abdominal circumference was of 97±22cm. The statin group comprised 18.2% of patients and had lower renal replacement therapy requirement and/or mortality (OR: 0.41; 95%CI: 0.18-0.93; p=0.03). The statin group also had lower risk of developing sepsis during intensive care unit stay (OR: 0.42; 95%CI: 0.22-0.77; p=0.006) and had a reduction in hospital length-of-stay (14.7±17.5 days versus 22.3±48 days; p=0.006). Statin therapy was associated with a protective role in critical care setting independently of confounding variables, such as gender, age, C-reactive protein, need of mechanical ventilation, use of pressor agents and presence of diabetes and/or coronary disease. Conclusion: Statin therapy prior to hospital admission was associated with lower mortality, lower renal replacement therapy requirement and sepsis rates. |
| Databáze: | OpenAIRE |
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