Aryl Hydrocarbon Receptor Activation Produces Heat Shock Protein 90 and 70 Overexpression, Prostaglandin E2/Wnt/β-Catenin Signaling Disruption, and Cell Proliferation in MCF-7 and MDA-MB-231 Cells after 24 h and 14 Days of Chlorpyrifos Treatment
| Autor: | Pilar Muñoz-Calero, Adela Pelayo, José Manuel García, Paula Moyano, María Teresa Frejo, A. Flores, Javier del Pino, Jimena García |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Toxicology
Dinoprostone Cell Line Tumor Heat shock protein Basic Helix-Loop-Helix Transcription Factors medicine Humans HSP70 Heat-Shock Proteins HSP90 Heat-Shock Proteins Prostaglandin E2 skin and connective tissue diseases Wnt Signaling Pathway Heat-Shock Proteins Cell Proliferation biology Chemistry Cell growth Wnt signaling pathway General Medicine Aryl hydrocarbon receptor Hsp90 Up-Regulation Hsp70 Receptors Aryl Hydrocarbon MCF-7 Cyclooxygenase 2 biology.protein Cancer research Chlorpyrifos Disinfectants medicine.drug |
| Zdroj: | Chemical Research in Toxicology. 34:2019-2023 |
| ISSN: | 1520-5010 0893-228X |
| DOI: | 10.1021/acs.chemrestox.1c00258 |
| Popis: | The biocide chlorpyrifos (CPF) was described to increase breast cancer risk in humans, to produce breast cancer in animals, and to induce cell proliferation in MCF-7 and MDA-MB-231 cells after 1 and 14 days of treatment. The entire mechanisms related to these CPF actions remain unknown. CPF induced cell proliferation in MCF-7 and MDA-MB-231 cells after 1 and 14 days of treatment by AhR activation through the PGE2/Wnt/β-catenin pathway and HSP90 and HSP70 overexpression. Our results reveal new information on CPF toxic mechanisms induced in human breast cancer cell lines, which could assist in elucidating its involvement in breast cancer. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|