Towards evidence-based vitamin D supplementation in infants: vitamin D intervention in infants (VIDI) — study design and methods of a randomised controlled double-blinded intervention study
| Autor: | Elisa Holmlund-Suila, Outi Mäkitie, Katri Räikkönen, Kati Heinonen, Sture Andersson, Jenni Rosendahl, Timo Hytinantti, Otto Helve, Helena Hauta-alus, Saara Valkama, Heli Viljakainen, Maria Enlund-Cerullo |
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| Přispěvatelé: | Clinicum, Children's Hospital, University of Helsinki, HUS Children and Adolescents, Department of Psychology and Logopedics, Medicum, Lastentautien yksikkö, Developmental Psychology Research Group |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
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Pediatrics D INSUFFICIENCY Allergy RESPIRATORY-INFECTIONS CHILDREN chemistry.chemical_compound Study Protocol 0302 clinical medicine Child Development Clinical Protocols 3123 Gynaecology and paediatrics 030212 general & internal medicine Vitamin D Cholecalciferol Evidence-Based Medicine DAY-CARE lcsh:RJ1-570 Bone development Vitamins 3. Good health Treatment Outcome Child Preschool Female Infants Vitamin medicine.medical_specialty Evidence-based practice 030209 endocrinology & metabolism Rickets Infections vitamin D deficiency Drug Administration Schedule CLINICAL-TRIAL D DEFICIENCY 03 medical and health sciences Double-Blind Method D-RECEPTOR Vitamin D and neurology medicine Humans Pediatrics Perinatology and Child Health EARLY-CHILDHOOD Dose-Response Relationship Drug business.industry Infant Newborn Immunity Infant lcsh:Pediatrics Evidence-based medicine COGNITIVE IMPAIRMENT medicine.disease Vitamin D Deficiency Asthma Clinical trial chemistry Immune System Pediatrics Perinatology and Child Health Dietary Supplements Cognitive development SERUM 25-HYDROXYVITAMIN D business |
| Zdroj: | BMC Pediatrics, Vol 17, Iss 1, Pp 1-8 (2017) BMC Pediatrics |
| ISSN: | 1471-2431 |
| DOI: | 10.1186/s12887-017-0845-5 |
| Popis: | Vitamin D is important for bone mass accrual during growth. Additionally, it is considered a requirement for a multitude of processes associated with, for example, the development of immunity. Many countries apply vitamin D supplementation strategies in infants, but the guidelines are not based on scientific evidence and aim at prevention of rickets. It remains unclear whether the recommended doses are sufficient for the wide array of other effects of vitamin D. The VIDI trial performed in Finland is the first large randomised controlled study for evaluation of the effects of different vitamin D supplemental doses in infancy on: VIDI, a randomised controlled double-blinded single-centre intervention study is conducted in infants from the age of 2 weeks to 24 months. Participants, recruited at Helsinki Maternity Hospital, are randomised to receive daily either 10 μg (400 IU) or 30 μg (1 200 IU) of vitamin D3 supplementation. Both groups are assessed at 6 months of age for calcium homeostasis, and at 12 and 24 months of age for parameters associated with bone strength, growth, developmental milestones, infections, immunity, atopy-related diseases, and genetic factors involved in these functions. The study enables evaluation of short and long term effects of supplemental vitamin D on growth, immune functions and skeletal and developmental parameters in infants, and the effects of genetic factors therein. The results enable institution of evidence-based guidelines for vitamin D supplementation in infancy. ClinicalTrials.gov, NCT01723852 , registration date 6.11.2012. |
| Databáze: | OpenAIRE |
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