Synthesis of cyclic oligopeptides containing an Arg-Gly-Asp (RGD) sequence
| Autor: | Takashi Takakuwa, Shosuke Sofuku, Takehiro Shimada, Akiko Hoshida, Yoichi Takada |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
chemistry.chemical_classification
Circular dichroism Oligopeptide Azides Stereochemistry General Chemistry General Medicine In Vitro Techniques Chemical synthesis Peptides Cyclic Cyclic peptide chemistry.chemical_compound Structure-Activity Relationship chemistry Cyclization Drug Discovery Peptide synthesis Peptide bond Platelet aggregation inhibitor Structure–activity relationship Humans Oligopeptides Platelet Aggregation Inhibitors |
| Zdroj: | Chemicalpharmaceutical bulletin. 47(12) |
| ISSN: | 0009-2363 |
| Popis: | The synthesis of cyclic RGD peptides with 8-10 residues cyclized by an amide bond and the relationship between their structure and activity (i.e. circular dichroism spectrum and inhibition of platelet aggregation) are reported. The linear peptides were synthesized by the solution method and their cyclization was performed in high dilution using DPPA. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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