Synthetic biodegradable medical polyurethanes
| Autor: | Gianluca Ciardelli, Susanna Sartori, Piergiorgio Gentile, Stefano Calzone, Chiono, Monica Boffito, Chiara Tonda-Turo, Clara Mattu |
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| Rok vydání: | 2017 |
| Předmět: |
chemistry.chemical_classification
Materials science Degradable polyurethane Polyurethane chemistry Polyurethane synthesis Polyurethanes for regenerative medicine Polyurethanes for tissue engineering Polymer science Natural polymers 02 engineering and technology Biodegradation 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Controlled release 0104 chemical sciences Polyol chemistry Tissue engineering Drug delivery Polymer chemistry Self-healing hydrogels Copolymer 0210 nano-technology |
| Popis: | Polyurethanes (PURs) are a class of block copolymers synthesised from three different reagents: a polyol, a di- or multi-isocyanate, and a chain extender. Biodegradable PURs can be synthesised by properly selecting the building blocks with suitable properties for applications in regenerative medicine. The nature and relative amount of hard and soft segments affect the mechanical properties. PURs can be bulk or surface functionalised with biomimetic peptide sequences or natural polymers, affecting cell response and/or the biodegradation rate. PUR particles, fibres, and hydrogels can be designed with a suitable composition for drug encapsulation and controlled release. This chapter offers an overview of the chemistry of biodegradable and biocompatible PURs and reports their application as scaffolds for tissue engineering and carriers for drug delivery. |
| Databáze: | OpenAIRE |
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