Effect of Antioxidant Echinochrome A on Bleomycin-Induced Pulmonary Fibrosis
| Autor: | O. V. Demidova, O. A. Lebed’ko, B. Ya. Ryzhavskii |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Pathology
medicine.medical_specialty Antioxidant medicine.medical_treatment Pulmonary Fibrosis Lumen (anatomy) Connective tissue Biology medicine.disease_cause Bleomycin General Biochemistry Genetics and Molecular Biology Antioxidants Muscle hypertrophy chemistry.chemical_compound Pulmonary fibrosis medicine Animals Lung General Medicine respiratory system medicine.disease respiratory tract diseases Rats medicine.anatomical_structure chemistry Infiltration (medical) Oxidative stress Naphthoquinones |
| Zdroj: | Bulletin of experimental biology and medicine. 159(3) |
| ISSN: | 1573-8221 |
| Popis: | We studied the protective effect of antioxidant echinochrome A on bleomycin-induced pulmonary fibrosis in rats at the early stages of postnatal ontogeny. Administration of echinochrome A was shown to reduce the severity of bleomycin-induced oxidative stress in the lungs, prevented the development of hypertrophy of interalveolar connective tissue and peribronchial lymphoid infiltration, and normalized the ratio of volume densities of interalveolar septa and alveolar lumen. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink