Double-Blind, Placebo-Controlled, Cross-Over Trial of Progabide as Add-On Therapy in Epileptic Patients
| Autor: | R. Santana, C. L'Héritier, S. Feldman, E. Gerstle de Pasquet, A. Scaramelli, P. L. Morselli, J. Aguilar, B. Musch, M. Piñeyrúa de Cáceres |
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| Rok vydání: | 1991 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Placebo GABAergic Agonist Placebos Double blind Double-Blind Method Liver Function Tests medicine Humans Drug Interactions Aspartate Aminotransferases Child gamma-Aminobutyric Acid Gynecology Epilepsy business.industry Alanine Transaminase Middle Aged Crossover study Surgery Add on therapy Liver Neurology Anticonvulsants Drug Therapy Combination Female Neurology (clinical) business Follow-Up Studies Progabide medicine.drug |
| Zdroj: | Epilepsia. 32:133-139 |
| ISSN: | 1528-1167 0013-9580 |
| Popis: | SUMMARY: In a double-blind, cross-over trial, progabide (PGB) and placebo were compared as add-on therapy in 59 patients with moderate to severe epilepsy. Eight patients did not complete the study, 4 because of adverse drug reactions (elevation of liver transaminases, 2; gastritis, 1; and acute psychosis, 1) and 4 because of administrative reasons. Among the remaining 51 patients, seizure frequency was reduced >50% in 18 patients with PGB treatment and in 8 patients with placebo (p |
| Databáze: | OpenAIRE |
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