The prognostic value of multivoxel magnetic resonance spectroscopy determined metabolite levels in white and grey matter brain tissue for adverse outcome in term newborns following perinatal asphyxia

Autor: Paul E. Sijens, Pieter Jan van Doormaal, Linda C. Meiners, Hendrik J. ter Horst, Christa N. van der Veere
Jazyk: angličtina
Rok vydání: 2012
Předmět:
Male
Pathology
Metabolite
INFANTS
Encephalopathy
Nerve Fibers
Myelinated
chemistry.chemical_compound
Prevalence
PROTON MR SPECTROSCOPY
Choline
Netherlands
Pediatric
Neurons
Asphyxia Neonatorum
medicine.diagnostic_test
Brain
General Medicine
Prognosis
Magnetic Resonance Imaging
Survival Rate
medicine.anatomical_structure
BIRTH ASPHYXIA
Radiology Nuclear Medicine and imaging
Female
Radiology
RELAXATION-TIMES
medicine.symptom
endocrine system
medicine.medical_specialty
Grey matter
Creatine
Asphyxia
Imaging
Three-Dimensional
AGE
Internal medicine
Magnetic resonance spectroscopy
medicine
Humans
Radiology
Nuclear Medicine and imaging
HYPOXIC-ISCHEMIC INJURY
business.industry
Neonatal encephalopathy
Infant
Newborn
NEONATAL ENCEPHALOPATHY
Magnetic resonance imaging
medicine.disease
Survival Analysis
Perinatal asphyxia
Endocrinology
Metabolism
chemistry
business
Zdroj: European Radiology, 22(4), 772-778. SPRINGER
European Radiology
ISSN: 0938-7994
Popis: Magnetic resonance spectroscopy can identify brain metabolic changes in perinatal asphyxia by providing ratios of metabolites, such as choline (Cho), creatine (Cr), N-acetyl aspartate (NAA) and lactate (Lact) [Cho/Cr, Lact/NAA, etc.]. The purpose of this study was to quantify the separate white and grey matter metabolites in a slab cranial to the ventricles and relate these to the outcome.A standard 2D-chemical shift imaging protocol was used for measuring a transverse volume of interest located cranial to the ventricles allowing for direct comparison of the metabolites in white and grey matter brain tissue in 24 term asphyxiated newborns aged 3 to 16 days.Cho, NAA and Lact showed significant differences between four subgroups of asphyxiated infants with more and less favourable outcomes. High levels of Cho and Lact in the grey matter differentiated non-survivors from survivors (P = 0.003 and P = 0.017, respectively).In perinatal asphyxia the levels of Cho, NAA and Lact in both white and grey matter brain tissue are affected. The levels of Cho and Lact measured in the grey matter are the most indicative of survival. It is therefore advised to include grey matter brain tissue in the region of interest examined by multivoxel MR spectroscopy.aEuro cent Magnetic resonance spectroscopy can identify brain metabolic changes in perinatal asphyxia.aEuro cent Choline and lactate levels in grey matter seem the best indicators of survival.aEuro cent Both grey and white matter should be examined during spectroscopy for perinatal asphyxia.
Databáze: OpenAIRE
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