Apolipoprotein E modulates glial activation and the endogenous central nervous system inflammatory response
| Autor: | Duncan Morgan, J. Mance, William D. Matthew, Daniel T. Laskowitz, John R. Lynch |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Lipopolysaccharides
Male Apolipoprotein E medicine.medical_specialty Lipopolysaccharide Immunology Central nervous system Gene Expression Stimulation Endogeny Biology Mice chemistry.chemical_compound Apolipoproteins E Internal medicine medicine Animals Immunology and Allergy RNA Messenger Interleukin 6 Cells Cultured Microglia Interleukin-6 Tumor Necrosis Factor-alpha Brain Mice Mutant Strains Mice Inbred C57BL Endocrinology medicine.anatomical_structure Neurology chemistry biology.protein Encephalitis lipids (amino acids peptides and proteins) Tumor necrosis factor alpha Neurology (clinical) Interleukin-1 |
| Zdroj: | Journal of Neuroimmunology. 114:107-113 |
| ISSN: | 0165-5728 |
| Popis: | Apolipoprotein E (apoE) is a 299 amino acid protein that is associated with risk of developing Alzheimer’s Disease (AD) and outcome after acute brain injury. To investigate the possibility that apoE modulates glial activation we studied the effect of endogenous apoE on inflammatory gene regulation in vitro and in vivo. Our results indicate that apoE downregulates CNS production of TNFα, Il-1β, and Il-6 mRNA following stimulation with lipopolysaccharide (LPS). This effect of endogenous apoE on inflammatory gene regulation appears to be specific, and may account for the biological role that apoE plays in acute and chronic human neurological disease. |
| Databáze: | OpenAIRE |
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