Regulation of Alternative Sigma Factor Use
Autor: | Sofia Österberg, Victoria Shingler, Teresa del Peso-Santos |
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Rok vydání: | 2011 |
Předmět: |
Genetics
Regulation of gene expression Bacteria Anti-sigma factors Sigma Factor DNA-Directed RNA Polymerases Gene Expression Regulation Bacterial Computational biology Biology Microbiology chemistry.chemical_compound Bacterial Proteins Holoenzymes chemistry Transcription (biology) Sigma factor RNA polymerase Gene Protein Binding Alarmone |
Zdroj: | Annual Review of Microbiology. 65:37-55 |
ISSN: | 1545-3251 0066-4227 |
Popis: | Alternative bacterial sigma factors bind the catalytic core RNA polymerase to confer promoter selectivity on the holoenzyme. The different holoenzymes are thus programmed to recognize the distinct promoter classes in the genome to allow coordinated activation of discrete sets of genes needed for adaptive responses. To form the holoenzymes, the different sigma factors must be available to compete for their common substrate (core RNA polymerase). This review highlights (a) the roles of antisigma factors in controlling the availability of alternative sigma factors and (b) the involvement of diverse regulatory molecules that promote the use of alternative sigma factors through subversion of the domineering housekeeping σ70. The latter include the nucleotide alarmone ppGpp and small proteins (DksA, Rsd, and Crl), which directly target the transcriptional machinery to mediate their effects. |
Databáze: | OpenAIRE |
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