Angiomatoid fibrosis histiocytoma in the pulmonary artery: A case report
| Autor: | Koji Azuhata, Kimihiro Shimizu, Shuji Mishima, Osamu Mishima, Nobuo Ito, Kenji Misawa, Hisashi Shimojo |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Pulmonary and Respiratory Medicine Adult Male Pathology medicine.medical_specialty angiomatoid fibrosis histiocytoma Case Report Case Reports 03 medical and health sciences 0302 clinical medicine Fibrosis medicine.artery pulmonary artery medicine Atypia Humans RC254-282 Histiocytoma medicine.diagnostic_test business.industry Neoplasms. Tumors. Oncology. Including cancer and carcinogens Nodule (medicine) General Medicine EWSR1‐CREB1 fusion medicine.disease 030104 developmental biology medicine.anatomical_structure Oncology Positron emission tomography 030220 oncology & carcinogenesis Pulmonary artery Cuff medicine.symptom business Artery Wedge resection (lung) |
| Zdroj: | Thoracic Cancer Thoracic Cancer, Vol 12, Iss 9, Pp 1453-1456 (2021) |
| ISSN: | 1759-7714 |
| Popis: | Angiomatoid fibrosis histiocytoma (AFH) is a rare neoplastic disease. Only one report has demonstrated an intraluminal tumor of the pulmonary artery (PA) corresponding to AFH to date. We describe the case of AFH with EWSR1‐CREB1 fusion occurring in the ascending artery. A 42‐year‐old man exhibited an abnormal nodule on chest computed tomography (CT) during checkup. It revealed an intraluminal mass in the ascending artery with significant metabolic uptake in positron emission tomography (PET)/CT. Therefore, right upper lobectomy with wedge resection of the PA trunk was performed. Histologically, the tumor was multinodular and surrounded by a dense lymphoplasmacytic cuff. Each nodule was composed of myxoid stroma and comprised ovoid or spindle cell fascicles with mild atypia. Fluorescent in situ hybridization (FISH) analysis confirmed EWSR1‐CREB1 fusion. A diagnosed as AFH was made. This report widens the spectrum of differential diagnoses of primary tumors occurring in the PA. Angiomatoid fibrosis histiocytoma (AFH) is a rare neoplastic disease. Only one report has demonstrated an intraluminal tumor of the pulmonary artery trunk corresponding to AFH with ESWR1‐ATF1 fusion to date. This is the first reported case of AFH occurring in the ascending artery with EWSR1‐CREB1 fusion. |
| Databáze: | OpenAIRE |
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