Statin-related Lichenoid Dermatosis: An Uncommon Adverse Reaction to a Common Treatment
| Autor: | Catarina Pires, Zsófia Vesza, Pedro Marques da Silva |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Statin medicine.drug_class lcsh:Medicine 030204 cardiovascular system & hematology Reductase statins 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Nutraceutical Internal Medicine medicine Rosuvastatin red yeast rice Adverse effect Secondary prevention nutraceuticals business.industry dyslipidemia lcsh:R nutritional and metabolic diseases Articles Dermatology Lichenoid drug eruption Simvastatin lipids (amino acids peptides and proteins) business medicine.drug |
| Zdroj: | European Journal of Case Reports in Internal Medicine, Vol 5, Iss 5 (2018) European Journal of Case Reports in Internal Medicine |
| ISSN: | 2284-2594 |
| Popis: | 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) are generally safe and well-tolerated drugs that are extensively used for the primary and secondary prevention of atherosclerotic cardiovascular events. Muscle and liver adverse reactions are the best recognized, while cutaneous side effects are exceedingly rare. We present the case of a 65-year-old woman with severe hypercholesterolemia, who developed generalized erythematous cutaneous lesions with pruritus, resembling lichen planus, months after starting treatment with simvastatin. The symptoms disappeared on withdrawal of simvastatin and reappeared within 3 months upon rechallenge with rosuvastatin. In addition to describing a rare adverse effect of statins, the authors also discuss the nutraceutical approach to the management of a statin-intolerant patient. LEARNING POINTS Lichenoid drug eruption is an uncommon cutaneous adverse effect of several drugs, with very few cases associated with statins. A temporal relationship, dechallenge/rechallenge information, and the lack of confounding factors or alternative explanations support the suggestion of causality. Due to the lack of optimized alternative treatment options for statin-intolerant patients, the nutraceutical approach should be considered. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|