ML355 Modulates Platelet Activation and Prevents ABT-737 Induced Apoptosis in Platelets

Autor:	Valentina Shpakova, Natalia Rukoyatkina, Nada Al Arawe, Anna Prilepskaya, Alexandra Kharazova, Iraida Sharina, Stepan Gambaryan, Emil Martin
Rok vydání:	2022
Předmět:	Blood Platelets Pharmacology Sulfonamides Platelet Aggregation Biphenyl Compounds Thrombin Apoptosis Platelet Activation Piperazines Nitrophenols Mice Phosphatidylinositol 3-Kinases Animals Molecular Medicine Platelet Aggregation Inhibitors
Zdroj:	Journal of Pharmacology and Experimental Therapeutics. 381:164-175
ISSN:	1521-0103 0022-3565
DOI:	10.1124/jpet.121.000973
Popis:	12-lipoxigenase (12-LOX) is implicated in regulation of platelet activation processes and can be a new promising target for antiplatelet therapy. However, investigations of 12-LOX were restricted by the lack of specific and potent 12-LOX inhibitors and by controversial data concerning the role of 12-LOX metabolites in platelet functions. A novel specific 12-LOX inhibitor ML355 was shown to inhibit platelet aggregation without adverse side effects on hemostasis; however, the molecular mechanisms of its action on platelets are poorly understood. Here, we showed that ML355 inhibited platelet activation induced by thrombin or thromboxane A
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79f09380f61085a1ebfb4be938cfa162 https://doi.org/10.1124/jpet.121.000973 Zobrazit plný text záznamu