Effects of L-Carnitine on Exercise Tolerance in Patients with Stable Angina Pectoris
| Autor: | Akira Kobayashi, Hideharu Hayashi, Tadashi Kamikawa, Noboru Yamazaki, Yoshikazu Suzuki, Kenji Nishihara, Masaaki Abe, Yoshinori Masumura |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1983 |
| Předmět: |
Adult
Male medicine.medical_specialty Exercise test Angina pectoris Physical Exertion Blood Pressure L-Carnitine Fatty Acids Nonesterified Angina Electrocardiography Heart Rate Carnitine Heart rate medicine ST segment Humans In patient Depression (differential diagnoses) Aged ST depression business.industry Middle Aged medicine.disease Surgery Rate pressure product Anesthesia Female medicine.symptom Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Japanese Heart Journal. 25(4):587-597 |
| ISSN: | 0021-4868 |
| Popis: | The effects of L-carnitine (900 mg, p.o. daily) on exercise performance were studied in 12 patients with stable effort angina using a multistage treadmill exercise test. Exercise tests were performed at the end of the placebo period and after 4 and 12 weeks of carnitine therapy. While 12 patients experienced angina during treadmill tests in the placebo period, 2 patients were free of angina after treatment with carnitine. The mean exercise time was 11.4 +/- 0.7 min (mean +/- SE) in the placebo period. This increased significantly to 12.2 +/- 0.5 min (p less than 0.05) after 4 weeks and 12.8 +/- 0.5 min (p less than 0.01) after 12 weeks of treatment with carnitine. The time required for 1 mm ST depression to occur was 6.4 +/- 0.9 min in the placebo period. This increased significantly to 7.6 +/- 0.9 min (p less than 0.01) after 4 weeks and 8.8 +/- 1.0 min after 12 weeks of treatment with carnitine. There was significantly less ST segment depression during the same exercise load after 12 weeks of treatment as compared with that in the placebo period (p less than 0.05). The heart rate and the pressure rate product at the same work load showed no significant difference among the 3 testing periods. The results of this study suggest that L-carnitine may improve exercise tolerance in patients with effort angina. |
| Databáze: | OpenAIRE |
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