Clinical interpretation of antineutrophil cytoplasmic antibodies: parvovirus B19 infection as a pitfall

Autor: D Stünzner, Josef Hermann, Ulrike Demel, E Daghofer, G Tilz, Winfried Graninger
Rok vydání: 2005
Předmět:
Adult
Vasculitis
Epstein-Barr Virus Infections
Adolescent
Concise Report
Mononucleosis
Myeloblastin
viruses
Immunology
Enzyme-Linked Immunosorbent Assay
Antibodies
Viral
General Biochemistry
Genetics and Molecular Biology
Antibodies
Antineutrophil Cytoplasmic
Autoimmune Diseases
Diagnosis
Differential
Parvoviridae Infections
Rheumatology
immune system diseases
hemic and lymphatic diseases
Parvovirus B19
Human
medicine
Humans
Immunology and Allergy
Outpatient clinic
cardiovascular diseases
skin and connective tissue diseases
Epstein–Barr virus infection
Peroxidase
Anti-neutrophil cytoplasmic antibody
Parvoviridae
biology
Parvovirus
business.industry
Serine Endopeptidases
Parvovirus infection
virus diseases
biology.organism_classification
medicine.disease
Virology
respiratory tract diseases
Immunoglobulin M
Acute Disease
biology.protein
Female
business
Biomarkers
Zdroj: Annals of the Rheumatic Diseases. 64:641-643
ISSN: 0003-4967
DOI: 10.1136/ard.2004.024877
Popis: While antibodies directed against proteinase 3 (PR3-ANCA) and myeloperoxidase (MPO-ANCA) have a high specificity for the diagnosis of systemic vasculitis, they may also be found as an epiphenomenon of acute viral infection.To investigate whether positive ANCA test results may be a common feature of acute parvovirus B19 infection.Sera were analysed from 1242 patients from a rheumatology outpatient clinic for reactivity with parvovirus B19 and EBV antibodies. They were tested for the presence of PR3-ANCA and MPO-ANCA, along with sera known to contain IgM antibodies to these viruses obtained from among 41,366 samples submitted for virological screening.ANCA were found in 10% (5/50) of the sera positive for IgM antibodies to parvovirus and in 3/51 sera containing IgM antibodies to EBV. Three of six patients with arthritis and concomitant parvovirus infection were found positive for PR3-ANCA and two were found positive for MPO-ANCA. All six patients tested negative for ANCA after six months of follow up.PR3-ANCA and MPO-ANCA may occur transiently in patients with acute B19 infection or infectious mononucleosis, highlighting the importance of repeated antibody tests in oligosymptomatic clinical conditions in which systemic autoimmune disease is suspected.
Databáze: OpenAIRE
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