Metal-free diastereoselective construction of bridged ketal spirooxindoles via a Michael addition-inspired sequence
| Autor: | Xuguan Bai, Shaojing Jin, Hua-Hui Dong, Qi-Lin Wang, Yan-Shuo Zhu, Jing Zhou, Zhanwei Bu, Jiaomei Guo |
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| Rok vydání: | 2017 |
| Předmět: |
010405 organic chemistry
Stereochemistry Chemistry Metals and Alloys Sequence (biology) General Chemistry 010402 general chemistry 01 natural sciences Combinatorial chemistry Catalysis 0104 chemical sciences Surfaces Coatings and Films Electronic Optical and Magnetic Materials Metal free Materials Chemistry Ceramics and Composites Michael reaction |
| Zdroj: | Chemical communications (Cambridge, England). 53(81) |
| ISSN: | 1364-548X |
| Popis: | A TfOH-catalyzed highly diastereoselective Michael addition/ketalization sequence of 3-hydroxyoxindoles and ortho-hydroxychalcones was developed, leading to biologically important bridged ketal spirooxindoles in moderate to excellent yields. Moreover, some chemical transformations were carried out to further extend the structural complexity and diversity. |
| Databáze: | OpenAIRE |
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