In vivo anti-diabetic effect of aqueous and methanolic macerated extracts of Atractylis gummifera
| Autor: | Fatima Lamchouri, Hamid Toufik, My El Abbes Faouzi, Mohamed Boulfia, Souad Senhaji, Khadija Bouabid |
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| Rok vydání: | 2019 |
| Předmět: |
Pharmacology
Gastric gavage 0303 health sciences Atractylis gummifera L Aqueous macerate business.industry lcsh:RM1-950 Diabetic mouse medicine.disease Metformin Fasting glucose 03 medical and health sciences Diabetes mellitus lcsh:Therapeutics. Pharmacology 0302 clinical medicine In vivo 030220 oncology & carcinogenesis Medicine business 030304 developmental biology Diabetic control medicine.drug Atractylis gummifera |
| Zdroj: | Bangladesh Journal of Pharmacology, Vol 14, Iss 2 (2019) |
| ISSN: | 1991-0088 |
| Popis: | The anti-diabetic effect of Atractylis gummifera (plant used in traditional Moroccan medicine) has been evaluated in type 2 diabetic mice model. The mice were divided into five groups: Normal control, diabetic control, diabetic treated with aqueous macerate (500 mg/kg), diabetic treated with methanol macerate (500 mg/kg) and diabetic treated with metformin (300 mg/kg). The treatment of the mice was performed by daily gastric gavage for 5 weeks. The monitoring of the mice was carried out weekly by fasting glucose and measurement of biochemical parameters at the end of treatment. The aqueous macerate of A. gummifera was most effective that reduced the fasting blood glucose with 62.7%. In addition, this extract restored the biochemical parameters of diabetic mice to normal. Video Clip of Methodolpogy: 5 min 53 sec: Full Screen Alternate |
| Databáze: | OpenAIRE |
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