The response ranges of pulmonary function and the impact criteria of weather and industrial influence on patients with asthma living in Vladivostok
| Autor: | Tatyana Gvozdenko, Elena Mineeva, Ludmila Veremchuk, Elena Grigorieva, Kirill Golokhvast, Tatyana Vitkina |
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| Rok vydání: | 2019 |
| Předmět: |
Environmental Engineering
Health Toxicology and Mutagenesis 02 engineering and technology 010501 environmental sciences 01 natural sciences Applied Microbiology and Biotechnology Pulmonary function testing Examination method 020401 chemical engineering Environmental health Asthma control medicine In patient 0204 chemical engineering Waste Management and Disposal 0105 earth and related environmental sciences Water Science and Technology Asthma Quality of Life Research business.industry Public Health Environmental and Occupational Health medicine.disease Pollution Disease control Uncontrolled asthma business Research Article |
| Zdroj: | J Environ Health Sci Eng |
| ISSN: | 2052-336X |
| Popis: | PURPOSE: To determine the response of pulmonary function (PF) to the influence of environmental factors in patients with different levels of asthma control. MATERIALS AND METHODS: Patients with controlled (136 people) and uncontrolled (96 people) asthma living in the conditions of monsoon climate and technogenic pollution in Vladivostok were examined. Discriminant analysis that provides the basis for dividing initial data into classes, as according to standards and expert estimates, was used to calculate ranges of PF response in asthma patients. The selection of discriminant functions with the highest values of constant and coefficient made it possible to identify the optimal quantitative ranges. RESULTS: Analysis of the discriminant value of Wilks’ lambda (α) has shown that the intensity of PF response to climatic and technogenic factors varies depending on level of disease control (controlled asthma – α = 0.67–0.79, uncontrolled asthma – α =0.05–0.44). The criteria and ranges of PF response also differ depending on level of disease control. In controlled asthma, PF response reflects an adaptive-compensatory dependence. The reaction to the environmental factors is rather weak; therefore, it could be detected by only more sensitive examination method (body plethysmography). In uncontrolled asthma, the response to the influence of environment quality is active and could be clearly identified by spirography. CONCLUSIONS: The climatic and technogenic environment of Vladivostok causes strong pathogenic impact on patients with uncontrolled asthma. The effects of dust fraction 0–1 μm, deeply penetrating into respiratory organs, and day-to-day variability of wind speed, which induces weather sensitivity, are particularly adverse. |
| Databáze: | OpenAIRE |
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