Chemopreventive Effects of Whole Cranberry ( Vaccinium macrocarpon ) on Colitis‐Associated Colon Tumorigenesis
| Autor: | Hang Xiao, Xian Wu, Catherine C. Neto, Qi Wang, Xiaokun Cai, Mingyue Song, Anuradha Tata, Yanhui Han, Zhonghai Tang |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Colorectal cancer Azoxymethane Mice Inbred Strains Biology medicine.disease_cause Metastasis Phosphatidylinositol 3-Kinases 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine food medicine Animals Anticarcinogenic Agents Vaccinium macrocarpon Colitis Cell Proliferation Neovascularization Pathologic Dextran Sulfate medicine.disease American cranberry food.food Enzymes 030104 developmental biology chemistry Cyclooxygenase 2 Apoptosis 030220 oncology & carcinogenesis Colonic Neoplasms Cancer research Cytokines Carcinogenesis Proto-Oncogene Proteins c-akt Food Science Biotechnology |
| Zdroj: | Molecular Nutrition & Food Research. 62:1800942 |
| ISSN: | 1613-4133 1613-4125 |
| Popis: | SCOPE There are growing interests in using a whole-food-based approach to prevent chronic diseases due to potential synergistic interactions among different bioactive components within the whole foods. North American cranberry (Vaccinium macrocarpon), a polyphenol-rich fruit, has been shown to exert multiple beneficial health effects. METHODS AND RESULTS For the first time, the protective effects of whole cranberry powder (WCP) are determined against colitis-associated mouse colon tumorigenesis induced by azoxymethane (AOM) and dextran sulfate sodium (DSS). The results show that dietary administration of WCP (1.5%, w/w in the diet) significantly suppresses colon tumorigenesis as indicated by the reduced tumor incidence, multiplicity, burden, and average tumor size in WCP-fed mice compared to the positive control mice. Both gene and protein expression levels of pro-inflammatory cytokines IL-1β, IL-6, and TNF-α are markedly attenuated by WCP treatment in the colon of AOM/DSS-treated mice. Moreover, WCP profoundly modulates multiple signaling pathways/proteins related to inflammation, cell proliferation, apoptosis, angiogenesis, and metastasis in the colon, which is closely associated with the inhibitory effects of WCP on colon tumorigenesis. CONCLUSION Overall, the results demonstrate chemopreventive effects of WCP on colon tumorigenesis in mice, providing a scientific basis for using the whole cranberry as a functional food to promote colon health in humans. |
| Databáze: | OpenAIRE |
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