Herpes simplex encephalitis occurring after chemotherapy, surgery, and stereotactic radiotherapy for medulloblastoma
| Autor: | S. Molloy, Michael A. Farrell, D. Allcutt, R A. Perryman, Paul Brennan, Francesca Brett |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Adult
medicine.medical_specialty Pathology Drug-Related Side Effects and Adverse Reactions viruses medicine.medical_treatment medicine.disease_cause Polymerase Chain Reaction Herpesviridae Pathology and Forensic Medicine Lesion Trigeminal ganglion Fatal Outcome Alphaherpesvirinae medicine Humans Simplexvirus Encephalitis Viral Cerebellar Neoplasms Medulloblastoma Chemotherapy biology Radiotherapy business.industry Brain Herpes Simplex General Medicine medicine.disease biology.organism_classification Combined Modality Therapy Surgery Medical Laboratory Technology Herpes simplex virus DNA Viral Female medicine.symptom business Encephalitis |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 0003-9985 |
| Popis: | Reactivation of latent herpes simplex virus (HSV) in the trigeminal ganglion most commonly gives rise to recurrent herpes labialis and rarely to herpes simplex encephalitis. The mechanisms underlying reactivation of latent trigeminal HSV are complex. Here we report the case history of a 25-year-old woman who developed a fatal, bilateral necrotizing destructive temporal lobe lesion following surgical removal of a cerebellar medulloblastoma and combined radiotherapy and chemotherapy for recurrent tumor. Neuropathologic examination of the brain revealed minimal inflammatory changes, but immunohistochemistry was positive for HSV protein, and HSV deoxyribonucleic acid (DNA) was recovered from formalin-fixed paraffin-embedded brain tissue. The temporal proximity of the surgery, chemotherapy, and radiotherapy to the onset of disease suggests that these factors may have acted as triggers that precipitated conversion of latent HSV to overt HSV. |
| Databáze: | OpenAIRE |
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