Intrastromal voriconazole: An adjuvant approach for recalcitrant mycotic keratitis
| Autor: | Shilpa Ajit Joshi, Madan Deshpande, Rasika R Thakur, Ashutosh Dayal, Seema J Mandhare, Piyali Konar |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Antifungal Agents medicine.medical_treatment Corneal Stroma Treatment outcome Hypopyon Causative organism lcsh:Ophthalmology Fungal keratitis medicine Adjuvant therapy Humans Prospective Studies recalcitrant ulcer Aged Voriconazole Aged 80 and over Keratitis Mycotic keratitis business.industry Fungi Middle Aged medicine.disease Surgery Ophthalmology Treatment Outcome lcsh:RE1-994 intrastromal voriconazole Female Original Article Injections Intraocular business Adjuvant Eye Infections Fungal medicine.drug Follow-Up Studies |
| Zdroj: | Indian Journal of Ophthalmology Indian Journal of Ophthalmology, Vol 68, Iss 1, Pp 35-38 (2020) |
| ISSN: | 1998-3689 |
| Popis: | Purpose: To evaluate the efficacy of intrastromal voriconazole for the management of fungal keratitis not responding to conventional therapy. Methods: Patients having microbiologically proven fungal keratitis with poor response to 2 weeks of conventional topical therapy were included in the study. After obtaining informed consent, an intrastromal injection of voriconazole was administered around the ulcer. Response to treatment in the form reduction in the size of the ulcer and infiltration was recorded on regular follow-ups. Results: Out of a total of 20 patients, 14 responded to intrastromal treatment and resolved, whereas six patients progressed to perforation. Mean resolution time was 35.5 ± 9.2 days. The most common organism isolated was Fusarium in six patients while Aspergillus and Mucor were isolated in two each. The causative organism could not be isolated in eight patients. The size of the ulcer at presentation and height of hypopyon were found to be significant risk factors associated with treatment outcomes. Conclusion: Intrastromal voriconazole as an adjuvant therapy appeared to be effective in treatment of fungal keratomycosis not responding to conventional therapy, thus, reducing the need for therapeutic or tectonic keratoplasty. |
| Databáze: | OpenAIRE |
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