Morbidity in New Zealand pesticide producers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)
| Autor: | David Scott, Amanda Eng, Pier Alberto Bertazzi, Evan Dryson, Dave McLean, Andrea 't Mannetje, Soo Cheng, Chris Walls, Collin Brooks, Jeroen Douwes, Simon Ryder-Lewis, Neil Pearce |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
Polychlorinated Dibenzodioxins Exposed Population Physiology 010501 environmental sciences 01 natural sciences Immunoglobulin G Interviews as Topic 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine High-density lipoprotein Occupational Exposure Diabetes mellitus Environmental health medicine Humans Pesticides lcsh:Environmental sciences 0105 earth and related environmental sciences General Environmental Science Subclinical infection lcsh:GE1-350 biology Cholesterol business.industry Lipid metabolism Middle Aged medicine.disease 030210 environmental & occupational health Occupational Diseases Cross-Sectional Studies Logistic Models Diabetes Mellitus Type 2 chemistry Chemical Industry biology.protein Female business Body mass index New Zealand |
| Zdroj: | Environment International, Vol 110, Iss, Pp 22-31 (2018) |
| ISSN: | 0160-4120 |
| Popis: | Objectives: To conduct a cross-sectional morbidity survey among 245 former employees of a pesticide production plant exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in New Zealand. Methods: Demographic factors and health information were collected in face-to-face interviews. TCDD, lipids, thyroid hormones, glucose and immunoglobulin G (IgG) were determined in non-fasting blood. For 111 participants, a neurological examination was conducted. Associations between health outcomes and working in a TCDD exposed job (prevalence 49%) and serum TCDD concentration≥10pg/g lipid (18%) were assessed using logistic regression whilst controlling for age, gender, smoking, body mass index and ethnicity. Results: Diabetes was more common in those who had worked in TCDD exposed jobs (OR 4.0, 95%CI 1.0–15.4) and in those with serum TCDD ≥10pg/g (OR 3.1, 95%CI 0.9–10.7). Non-fasting glucose levels >6.6mmol/l were more common in those with TCDD exposed jobs (OR 3.6, 95%CI 1.0–12.9), as were serum free thyroxine 41.7mmol/l (OR 2.5, 95%CI 1.1–5.7) and high density lipoprotein cholesterol (HDL) |
| Databáze: | OpenAIRE |
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