Reconstructing Mayaro virus circulation in French Guiana shows frequent spillovers
| Autor: | Antoine Enfissi, Matthieu Najm, Sarah Bailly, Nathanaël Hozé, Dominique Rousset, Jessica Vanhomwegen, Jean-Claude Manuguerra, Camille Fritzell, Claude Flamand, Simon Cauchemez, Henrik Salje |
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| Přispěvatelé: | Modélisation mathématique des maladies infectieuses - Mathematical modelling of Infectious Diseases, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Centre National de Référence pour les Arbovirus - Laboratoire associé de Virologie [Cayenne, Guyane] (CNR), Institut Pasteur de la Guyane, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Unité d'Epidémiologie, Environnement et Risques infectieux - Environment and Infectious Risks (ERI), Institut Pasteur [Paris], This study was supported by the 'European Regional Development Fund' under EPI-ARBO grant agreement (GY0008695), the 'Regional Health Agency of French Guiana', the 'National Center of Spatial Studies'. C.Fl. and C. Fr. acknowledge funding from Calmette and Yersin allocated by the 'Pasteur Institut Department of International Affairs'. N.H. and S.C. acknowledge financial support from the AXA Research Fund, the Investissement d’Avenir program, the Laboratoire d’Excellence Integrative Biology of Emerging Infectious Diseases program (Grant ANR-10-LABX-62-IBEID), the Models of Infectious Disease Agent Study of the National Institute of General Medical Sciences, the INCEPTION project (PIA/ANR-16-CONV-0005), the European Union’s Horizon 2020 research and innovation programme under ZIKAlliance grant agreement No. 734548., We wish to thank Mirdad Kazanji (Institut Pasteur in French Guiana), Félix Djossou (Cayenne hospital center), Sandrine Fernandes-Pellerin (Institut Pasteur - CRT), and Léna Berthelot, Séverine Matheus, Laetitia Bremand, Bhety Labeau, David Moua, and Marine Rangon from the Arbovirus National Reference Center for their valuable contribution in the laboratory analyses. We thank Juliette Paireau and Quirine ten Bosch for insightful discussions., ANR-10-LABX-62-IBEID,IBEID,Laboratoire d'Excellence 'Integrative Biology of Emerging Infectious Diseases'(2010), ANR-16-CONV-0005,INCEPTION,Institut Convergences pour l’étude de l’Emergence des Pathologies au Travers des Individus et des populatiONs(2016), European Project: 734548,ZIKAlliance(2016), University of Cambridge [UK] (CAM), Centre National de Référence pour les Arbovirus - Laboratoire de Virologie [Cayenne, Guyane française] (CNR - laboratoire associé), Réseau International des Instituts Pasteur (RIIP), ANR-10-LABX-0062,IBEID,Integrative Biology of Emerging Infectious Diseases(2010), ANR-16-CONV-0005,INCEPTION,Institut Convergences pour l'étude de l'Emergence des Pathologies au Travers des Individus et des populatiONs(2016), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Institut Pasteur [Paris] (IP), Hozé, Nathanaël [0000-0002-3977-8966], Salje, Henrik [0000-0003-3626-4254], Rousset, Dominique [0000-0002-1473-3147], Manuguerra, Jean-Claude [0000-0002-5202-6531], Flamand, Claude [0000-0002-8064-445X], Apollo - University of Cambridge Repository |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine Statistical methods Epidemiology [SDV]Life Sciences [q-bio] viruses General Physics and Astronomy Rural Health Antibodies Viral medicine.disease_cause Communicable Diseases Emerging Viral infection MESH: Cross Reactions 13/1 Seroepidemiologic Studies [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases MESH: Arboviruses MESH: Child MESH: Communicable Diseases Emerging 692/308/174 Chikungunya [MATH]Mathematics [math] Child MESH: Alphavirus Infections lcsh:Science MESH: Immunoglobulin G [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases Multidisciplinary MESH: Middle Aged article virus diseases Middle Aged 631/114/2415 MESH: Infant French Guiana 3. Good health [STAT]Statistics [stat] Geography MESH: Young Adult Child Preschool Epidemiological Monitoring [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology Female Sylvatic cycle Chikungunya virus Adult Adolescent Science 030106 microbiology Cross Reactions Arbovirus General Biochemistry Genetics and Molecular Biology Virus Young Adult 03 medical and health sciences MESH: Cross-Sectional Studies 692/699/255/2514 Environmental health MESH: French Guiana medicine Humans Natural reservoir Viral immunology MESH: Adolescent MESH: Seroepidemiologic Studies MESH: Humans Alphavirus Infections MESH: Child Preschool Infant [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry Molecular Biology/Molecular biology MESH: Adult MESH: Chikungunya virus General Chemistry MESH: Rural Health biochemical phenomena metabolism and nutrition medicine.disease MESH: Male Cross-Sectional Studies 030104 developmental biology Immunoglobulin G [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie lcsh:Q MESH: Epidemiological Monitoring MESH: Female Arboviruses MESH: Antibodies Viral |
| Zdroj: | Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020) Nature Communications Nature Communications, Nature Publishing Group, 2020, 11 (1), pp.2842. ⟨10.1038/s41467-020-16516-x⟩ Nature Communications, 2020, 11 (1), pp.2842. ⟨10.1038/s41467-020-16516-x⟩ |
| ISSN: | 2041-1723 |
| Popis: | Characterizing the circulation of Mayaro virus (MAYV), an emerging arbovirus threat, is essential for risk assessment but challenging due to cross-reactivity with other alphaviruses such as chikungunya virus (CHIKV). Here, we develop an analytical framework to jointly assess MAYV epidemiology and the extent of cross-reactivity with CHIKV from serological data collected throughout French Guiana (N = 2697). We find strong evidence of an important sylvatic cycle for MAYV with most infections occurring near the natural reservoir in rural areas and in individuals more likely to go to the forest (i.e., adult males) and with seroprevalences of up to 18% in some areas. These findings highlight the need to strengthen MAYV surveillance in the region and showcase how modeling can improve interpretation of cross-reacting assays. Mayaro virus (MAYV) is an emerging arbovirus, but cross-reactivity with other alphaviruses makes analysis of its epidemiology difficult. Here, the authors develop an analytical framework to assess MAYV epidemiology and find evidence for an important sylvatic cycle and seroprevalences of up to 18% in some areas of French Guiana. |
| Databáze: | OpenAIRE |
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