Peptide cyclisation promoted by supramolecular complex formation

Autor:	Arnout P. T. Hartendorp, Felix J. de Zwart, Hans Bieräugel, Bas de Bruin, Joost N. H. Reek, Jan H. van Maarseveen
Přispěvatelé:	Homogeneous and Supramolecular Catalysis (HIMS, FNWI), HIMS (FNWI), HCSC+ (HIMS, FNWI), Synthetic Organic Chemistry (HIMS, FNWI)
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	Organic Chemistry technology industry and agriculture macromolecular substances Physical and Theoretical Chemistry Biochemistry
Zdroj:	Organic and Biomolecular Chemistry, 20(3), 575-578. Royal Society of Chemistry
ISSN:	1477-0539 1477-0520
DOI:	10.1039/d1ob02309h
Popis:	Phenol ester activated dipeptides that are reluctant to ring-close have been cyclised with the aid of sterically shielding metallo-porphyrins avoiding unwanted intermolecular reactions. The binding of ZnTPP to the dipyridine-functionalised activating phenolic ester was studied by NMR titrations and modelling. Staudinger-mediated cyclisations in the presence of ZnTPP increased the yield of the cyclic dipeptide from 16% to 40%.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79e318981c6513cf5ec49d44ea4e180a https://doi.org/10.1039/d1ob02309h Zobrazit plný text záznamu