Spontaneous failure of the estrous cycle induces anxiogenic-related behaviors in middle-aged female mice
| Autor: | Jeferson S. Cavalcante, Rovena C.G.J. Engelberth, Elaine C. Gavioli, Rebecca A.M. Guimarães, Laila Asth, Vanessa de Paula Soares-Rachetti |
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| Rok vydání: | 2015 |
| Předmět: |
Aging
medicine.medical_specialty medicine.drug_class Estrous Cycle Experimental and Cognitive Psychology Anxiety Open field Mice Behavioral Neuroscience Internal medicine Electrochemistry medicine Animals Single-Blind Method Young adult Maze Learning Swimming Estrous cycle Estrogens medicine.disease Menopause Disease Models Animal Endocrinology Anxiogenic Estrogen Exploratory Behavior Female medicine.symptom Psychology Locomotion Psychopathology |
| Zdroj: | Physiology & Behavior. 147:319-323 |
| ISSN: | 0031-9384 |
| DOI: | 10.1016/j.physbeh.2015.05.009 |
| Popis: | Clinical studies have shown that women during perimenopause and menopause have a higher incidence in the diagnoses of psychiatric problems compared with men. However, little literature information about the influence of spontaneous perimenopause on anxiety- and mood-related behaviors in mice is available. To this aim, we compared the behavioral responses of middle-aged and young adult female mice both in the diestrus phase in the elevated plus-maze, open field and forced swimming tests. In middle-aged mice, the duration of the estrous cycle was significantly prolonged compared to young adults, thus indicating that our middle-aged mice are in the perimenopausal period. In the elevated plus-maze test, middle-aged mice explored less the open arms when compared to young adults, suggesting an anxiogenic-like phenotype. No significant differences were observed in the estrogen plasma levels and emotional behavior in the forced swim and open field tests. In conclusion, the spontaneous failure of the estrous cycle increased anxiety in middle-aged females. These data suggest that the perimenopausal period has a significant influence on anxiety-related behaviors in female mice. |
| Databáze: | OpenAIRE |
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