Guanylyl Cyclase-Linked Receptors
| Autor: | P. S. T. Yuen, D. L. Garbers |
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| Rok vydání: | 1992 |
| Předmět: | |
| Zdroj: | Annual Review of Neuroscience. 15:193-225 |
| ISSN: | 1545-4126 0147-006X |
| DOI: | 10.1146/annurev.ne.15.030192.001205 |
| Popis: | Cyclic GMP was identified as a component of urine in 1 963 (Ashman et al) shortly after the classical works of Sutherland & RaIl had proposed the second messenger hypothesis (RaIl et al 1 957, Rall & Sutherland 1 958, Sutherland & RaIl 1957, 1 958, 1 960). Guanylyl cyclase and cyclic nucleo tide phosphodiesterase activities were subsequently reported to exist in virtually all tissues (Appleman et al 1973, Hardman et al 1 97 1 , Hardman & Sutherland 1969, Ishikawa et al 1969, Schultz et al 1 969, White & Aurbach 1 969), and cyclic GMP concentrations were shown to change in response to a wide variety of different agents, including hormones and neurotransmitters (Goldberg & Haddox 1 977). Progress in understanding the mechanisms by which cellular cyclic GMP concentrations were elevated in response to these various agents moved rather slowly, however, in part, because guanylyl cyclase (enzyme activity is found in both soluble and particulate fractions of most tissue homogenates) could not be activated in broken cell preparations (Murad et al 1979). That guanylyl cyclases in both particulate and soluble fractions of tissue homogenates serve as receptors for a variety of different and specific ligands has become realized over the last ten years. This review con centrates on the guanylyl cyclase/receptor family and the nature of the ligands that specifically bind and activate these receptors. Other recent reviews that address this topic include Brenner et al ( 1 990), Chinkers & Garbers ( 199 1), Garbers ( 1 989a,b), and Inagami ( 1989). |
| Databáze: | OpenAIRE |
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