Evaluation and Management of Skeletal Health in Celiac Disease: Position Statement
| Autor: | Lorena P. Rios, Karen McAssey, Aliya Khan, David Armstrong, Muhammad Sultan, Mona A. Fouda |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Position statement
Adult Male medicine.medical_specialty Pathology Bone density Article Subject Osteoporosis MEDLINE Disease Review Sex Factors Clinical Protocols Sex factors Bone Density Internal medicine medicine Humans In patient lcsh:RC799-869 Child Bone mineral business.industry Gastroenterology Age Factors General Medicine medicine.disease Bone Diseases Metabolic Celiac Disease Female lcsh:Diseases of the digestive system. Gastroenterology business Corrigendum |
| Zdroj: | Canadian Journal of Gastroenterology, Vol 26, Iss 11, Pp 819-829 (2012) Canadian Journal of Gastroenterology & Hepatology |
| ISSN: | 0835-7900 |
| Popis: | OBJECTIVE: To review the evaluation and management of skeletal health in patients with celiac disease (CD), and to make recommendations on screening, diagnosis, treatment and follow-up of low bone mineral density (BMD) in CD patients.METHODS: A multidisciplinary team developed clinically relevant questions for review. An electronic search of the literature was conducted using the MEDLINE and EMBASE databases from 1996 to 2010. All original studies, reviews and guidelines, both pediatric and adult, were included. A document summarizing the results of the review and proposed recommendations was prepared and underwent multiple revisions until consensus was reached.RESULTS: At diagnosis, approximately one-third of adult CD patients have osteoporosis, one-third have osteopenia and one-third have normal BMD. Children with CD have low bone mass at diagnosis. Adult and pediatric CD patients are at increased risk of fractures.DISCUSSION: For adults, serum calcium, albumin, 25(OH) vitamin D3, parathyroid hormone and 24 h urine calcium testing should be performed at diagnosis; patients with ‘classic’ CD and those at risk for osteoporosis should undergo a dual x-ray absorptiometry scan. An abnormal baseline dual x-ray absorptiometry scan should be repeated one to two years after initiation of a gluten-free diet (GFD). For children, BMD should be assessed one year after diagnosis if GFD adherence is not strict. A GFD is the most important treatment for bone loss. Supplemental antiresorptives may be justified in those who remain at high fracture risk (eg, postmenopausal women, older men) after implementation of a GFD.CONCLUSION: Current evidence does not support the screening of all CD patients for low BMD at diagnosis. Follow-up BMD assessment should be performed one to two years after initiation of a GFD. |
| Databáze: | OpenAIRE |
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