Magnetic hydrogel with long in situ retention time for self-regulating temperature hyperthermia
| Autor: | Chengwei Wu, Heng Li, Xiaogang Yu, Wei Zhang, Renpeng Yang, Li Yu, Ding Shuaiwen, Yuxiang Zhang |
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| Rok vydání: | 2021 |
| Předmět: |
Hyperthermia
In situ magnetic nanoparticles Cancer Research Materials science Biocompatibility Physiology magnetic hydrogel hyperthermia medicine.disease 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine self-regulating temperature biocompatibility 030220 oncology & carcinogenesis Physiology (medical) Self-healing hydrogels Medical technology medicine Biophysics Magnetic nanoparticles Redistribution (chemistry) R855-855.5 Retention time |
| Zdroj: | International Journal of Hyperthermia, Vol 38, Iss 1, Pp 13-21 (2021) |
| ISSN: | 1464-5157 0265-6736 |
| DOI: | 10.1080/02656736.2020.1863479 |
| Popis: | Aim: Magnetic hydrogels (MHGs) have been proposed to avoid the redistribution and loss of magnetic nanoparticles (MNPs) when administrated by intratumoral injection. However, the requirement of complex cooling systems and temperature monitoring systems still hinder the clinical application of MHGs. This study investigates the feasibility of developing an MHG to realize the self-regulation of hyperthermia temperature. Methods: The MHG was developed by dispersing the MNPs with self-regulating temperature property into the temperature-sensitive hydrogel through physical crosslinking. The MHG's gelation temperature was tested by measuring the storage modulus and loss modulus on a rotational rheometer. The biocompatibility of the MHG and MNPs was characterized by CCK-8 assay against HaCaT cells. The in vivo magnetic heating property was examined through monitoring the temperature in the MHG on mice back upon the application of the alternating magnetic field (400 ± 5 Oe, 100 ± 5 kHz) every week for successive six weeks. Results: The gelation temperature of the MHG falls in 28.4°C-37.4°C. At in vivo applied concentration of 80 mg/mL, the MHG exhibits over 80% cell viability after 72 h, significantly higher than 50% cell viability of the MNPs (pConclusions: The developed MHG can be injected using a syringe and will solidify upon body temperature. The biocompatibility is improved after the MNPs being made into MHG. The MHG can self-regulate the temperature for six weeks, exhibiting application potential for self-regulating temperature hyperthermia. |
| Databáze: | OpenAIRE |
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