Characterization of a highly divergent TT virus genome
| Autor: | R. L. Hallett, J. P. Clewley, P. J. McKiernan, F. Bobet, C. G. Teo |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Torque teno virus
Genetics Whole genome sequencing Genetic diversity biology Molecular Sequence Data Genome Viral biology.organism_classification Virology Genome DNA Virus Infections United Kingdom DNA sequencing Virus Open Reading Frames Genetic distance DNA Viral Prevalence Humans Nucleic Acid Conformation Circoviridae Phylogeny Virus classification |
| Zdroj: | Journal of General Virology. 81:2273-2279 |
| ISSN: | 1465-2099 0022-1317 |
| DOI: | 10.1099/0022-1317-81-9-2273 |
| Popis: | A novel TT virus (TTV)-like DNA sequence was detected in the serum of a patient (PM) with acute non-A–E hepatitis. The full-length genome sequence, referred to here as PM virus (PMV), was obtained and its relationship to other full or near full-length TTV sequences examined. Although it shares a common genomic arrangement and short conserved regions, the majority of the genome is extremely divergent, displaying an average genetic distance of 0·60 from all other TTV sequences. By comparing PMV with TTV genomes representing the most divergent types so far described, six major groups can be distinguished. The level of genetic diversity seen between these genomes is higher than would be expected within a single virus species. Indeed, PMV could be considered the prototype of an independent taxonomic group within the Circoviridae family. A genoprevalence study of sera from blood donors and patients with acute hepatitis suggests that PMV is rare. |
| Databáze: | OpenAIRE |
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