Mitonuclear interactions and introgression genomics of macaque monkeys ( Macaca ) highlight the influence of behaviour on genome evolution
| Autor: | Noviar Andayani, Anthony J. Tosi, Jatna Supriatna, Jianlong Zhu, Don J. Melnick, Benjamin M. Peter, Ben J. Evans |
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| Rok vydání: | 2021 |
| Předmět: |
Male
0106 biological sciences Genome evolution Introgression Genomics 010603 evolutionary biology 01 natural sciences Macaque Genome General Biochemistry Genetics and Molecular Biology Gene flow Divergence Evolution Molecular 03 medical and health sciences biology.animal Animals 030304 developmental biology General Environmental Science 0303 health sciences Natural selection General Immunology and Microbiology biology Genetics and Genomics Haplorhini General Medicine Evolutionary biology Genome Mitochondrial Macaca Female General Agricultural and Biological Sciences |
| Zdroj: | Proc Biol Sci |
| ISSN: | 1471-2954 0962-8452 |
| DOI: | 10.1098/rspb.2021.1756 |
| Popis: | In most macaques, females are philopatric and males migrate from their natal ranges, which results in pronounced divergence of mitochondrial genomes within and among species. We therefore predicted that some nuclear genes would have to acquire compensatory mutations to preserve compatibility with diverged interaction partners from the mitochondria. We additionally expected that these sex-differences would have distinctive effects on gene flow in the X and autosomes. Using new genomic data from 29 individuals from eight species of Southeast Asian macaque, we identified evidence of natural selection associated with mitonuclear interactions, including extreme outliers of interspecies differentiation and metrics of positive selection, low intraspecies polymorphism and atypically long runs of homozygosity associated with nuclear-encoded genes that interact with mitochondria-encoded genes. In one individual with introgressed mitochondria, we detected a small but significant enrichment of autosomal introgression blocks from the source species of her mitochondria that contained genes which interact with mitochondria-encoded loci. Our analyses also demonstrate that sex-specific demography sculpts genetic exchange across multiple species boundaries. These findings show that behaviour can have profound but indirect effects on genome evolution by influencing how interacting components of different genomic compartments (mitochondria, the autosomes and the sex chromosomes) move through time and space. |
| Databáze: | OpenAIRE |
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