Evaluation of hyperacute infarct volume using ASPECTS and brain CT perfusion core volume
Autor: | Christopher Levi, Mark W Parsons, Andrew Bivard, Patrick McElduff, Carlos Garcia-Esperon, Pablo García-Bermejo, Fouke Ombelet, Jelle Demeestere |
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Rok vydání: | 2017 |
Předmět: |
Male
Contrast Media Infarction Perfusion scanning 030204 cardiovascular system & hematology Severity of Illness Index Article Brain Ischemia Pattern Recognition Automated Lesion 03 medical and health sciences 0302 clinical medicine Interquartile range Image Interpretation Computer-Assisted Medical imaging Humans Medicine Single-Blind Method Stroke Aged Retrospective Studies Aged 80 and over business.industry Brain Prognosis medicine.disease Diffusion Magnetic Resonance Imaging Early Diagnosis Treatment Outcome ROC Curve Female Neurology (clinical) Tomography medicine.symptom Tomography X-Ray Computed business Nuclear medicine Perfusion 030217 neurology & neurosurgery |
Zdroj: | Neurology |
ISSN: | 1526-632X 0028-3878 |
Popis: | Objective:To compare the accuracy of Alberta Stroke Program Early Computed Tomography Score (ASPECTS) and CT perfusion to detect established infarction in acute anterior circulation stroke.Methods:We performed an observational study in 59 acute anterior circulation ischemic stroke patients who underwent brain noncontrast CT, CT perfusion, and MRI within 100 minutes from CT imaging. ASPECTS scores were calculated by 4 blinded vascular neurologists. The accuracy of ASPECTS and CT perfusion core volume to detect an acute MRI diffusion lesion of ≥70 mL was evaluated using receiver operating characteristics analysis and optimum cutoff values were calculated using Youden J.Results:Median ASPECTS score was 8 (interquartile range [IQR] 5–9). Median CT perfusion core volume was 22 mL (IQR 10.4–71.9). Median MRI diffusion lesion volume was 24.5 mL (IQR 10–63.9). No significant difference was found between the accuracy of CT perfusion and ASPECTS (c statistic 0.95 vs 0.87, p value for difference = 0.17). The optimum ASPECTS cutoff score to detect a diffusion-weighted imaging lesion ≥70 mL was R = 0.88; R2 = 0.77).Conclusions:We found no significant difference between the accuracy of CT perfusion and ASPECTS to predict hyperacute MRI lesion volume in ischemic stroke. |
Databáze: | OpenAIRE |
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