Motilin effects on the proximal stomach in patients with functional dyspepsia and healthy volunteers
| Autor: | Rik C. Schoemaker, Adam F. Cohen, Izak Biemond, Ad A.M. Masclee, Aernout D. van Haarst, Ingrid M C Kamerling, Richard Jones, Jacobus Burggraaf, Hartmut Heinzerling |
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| Rok vydání: | 2003 |
| Předmět: |
Adult
Male medicine.medical_specialty Physiology Gastroenterology Motilin Gastrointestinal Agents Physiology (medical) Internal medicine Healthy volunteers medicine Humans In patient Dyspepsia Proximal stomach Hepatology business.industry Stomach digestive oral and skin physiology Muscle Smooth Nausea Middle Aged Barostat medicine.anatomical_structure Gastrointestinal hormone Female business hormones hormone substitutes and hormone antagonists Muscle Contraction |
| Zdroj: | American Journal of Physiology-Gastrointestinal and Liver Physiology. 284:G776-G781 |
| ISSN: | 1522-1547 0193-1857 |
| DOI: | 10.1152/ajpgi.00456.2002 |
| Popis: | This study investigates motilin effects on the proximal stomach in patients with functional dyspepsia (FD) and healthy volunteers. Eight healthy volunteers and 12 patients with FD were infused with synthetic motilin or placebo. Proximal gastric volume was measured with a barostat at constant pressure and during isobaric distensions. Abdominal symptoms were scored by visual analog scales. Plasma motilin concentrations were measured by radioimmunoassay. Motilin concentrations and baseline gastric volumes were similar for patients and healthy volunteers. Motilin, compared with placebo, reduced gastric volume by 112 ml [ F(29,195); confidence interval (CI) 95%] in patients and by 96 ml [ F(−7,200); CI 95%] in healthy volunteers. In patients, motilin decreased compliance by 76 ml/mmHg [ F(9,143); CI 95%] compared with placebo, which was similar in volunteers [66 ml/mmHg; F(11,120); CI 95%]. Patients were more nauseous during motilin compared with placebo ( P = 0.04), whereas healthy volunteers did not experience nausea. We conclude that in a fasted condition, FD patients have a similar proximal gastric motor response to motilin as healthy volunteers, but experience an exaggerated sensation of nausea. |
| Databáze: | OpenAIRE |
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