Deconstruction of Corticospinal Circuits for Goal-Directed Motor Skills
| Autor: | Zhigang He, Xinjian Li, Mengying Chen, Yuanyuan Liu, Philip R. Williams, Kush Kapur, Noaf Salah Ali Alwahab, Haixia Ding, Zicong Zhang, Charles R. Gerfen, Yiming Zhang, Xuhua Wang, Bin Yu, Kuan Hong Wang, Hengfu Yang, Yu Zhang |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Biology General Biochemistry Genetics and Molecular Biology Article Task (project management) 03 medical and health sciences Mice 0302 clinical medicine Forelimb Neural Pathways medicine Animals Motor skill Cerebral Cortex Motor control Cervical Cord Anatomy Spinal cord Mice Inbred C57BL 030104 developmental biology medicine.anatomical_structure Motor Skills Calcium Joints Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Cell. 171(2) |
| ISSN: | 1097-4172 |
| Popis: | Corticospinal neurons (CSNs) represent the direct cortical outputs to the spinal cord and play important roles in motor control across different species. However, their organizational principle remains unclear. By using a retrograde labeling system, we defined the requirement of CSNs in the execution of a skilled forelimb food-pellet retrieval task in mice. In vivo imaging of CSN activity during performance revealed the sequential activation of topographically ordered functional ensembles with moderate local mixing. Region-specific manipulations indicate that CSNs from caudal or rostral forelimb area control reaching or grasping, respectively, and both are required in the transitional pronation step. These region-specific CSNs terminate in different spinal levels and locations, therefore preferentially connecting with the premotor neurons of muscles engaged in different steps of the task. Together, our findings suggest that spatially defined groups of CSNs encode different movement modules, providing a logic for parallel-ordered corticospinal circuits to orchestrate multistep motor skills. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|