Specific features of the immune status and interferon system of infants
| Autor: | M. V. Kushnareva, T. V. Vinogradova, E. S. Keshishian, V. V. Parfenov, V. D. Koltsov, G. S. Bragina, O. V. Parshina, T. S. Guseva |
|---|---|
| Jazyk: | ruština |
| Rok vydání: | 2016 |
| Předmět: |
frequently ill children
Immune status medicine.medical_treatment Immunosuppression interferon Biology medicine.disease Pediatrics RJ1-570 Complement system immune system Immune system Antigen children Humoral immune deficiency Interferon Primary immune response Pediatrics Perinatology and Child Health Immunology medicine infancy medicine.drug |
| Zdroj: | Rossijskij Vestnik Perinatologii i Pediatrii, Vol 61, Iss 3, Pp 12-21 (2016) |
| ISSN: | 2500-2228 1027-4065 |
| Popis: | The paper summarizes research material on viral or bacterial infections and inflammatory diseases in infants, which are represented by the specific features of the development of the immune system as a whole, including the interferon system. This age period is characterized by physiological humoral immune deficiency; decreased activation of the complement system; insufficient synthesis of cytokines, including interferons; T-cell immunosuppression; impaired intercellular cooperation, and a weak functional activity | of natural killer cells and phagocytes. In this period, information on environmental antigens is accumulated in the presence of a primary immune response, which does not ensure a steady anti-infectious defense. In spite of the available large arsenal of antiviral agents and methods to prevent viral and bacterial infections and inflammatory diseases, there is a search for novel approaches to treating infectious diseases with consideration for the specific features of the immune status in infants. |
| Databáze: | OpenAIRE |
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