The evidence of indirect transmission of SARS-CoV-2 reported in Guangzhou, China
| Autor: | Kuibiao Li, Xiao Zhang, Jiachun Lu, Jin Chen, Chaojun Xie, Dahu Wang, Hongjun Zhao, Lin Zhang, Huide Peng, Xiaoxiao Lu, Jun Yuan, Di Wu, Yuzhou Gu, Zhoubin Zhang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty China Indirect Transmission Cross-sectional study Pneumonia Viral 030209 endocrinology & metabolism Snot-oral transmission Real-Time Polymerase Chain Reaction law.invention 03 medical and health sciences Betacoronavirus 0302 clinical medicine law Residence Characteristics Environmental health Pandemic Epidemiology medicine Environmental Microbiology Cluster Analysis Humans Severe acute respiratory syndrome coronavirus 2 Family 030212 general & internal medicine Pandemics Aged Novel coronavirus disease business.industry SARS-CoV-2 Public health lcsh:Public aspects of medicine Public Health Environmental and Occupational Health COVID-19 lcsh:RA1-1270 Middle Aged Transmission (mechanics) Cross-Sectional Studies Indirect transmission Female Biostatistics Contact Tracing business Coronavirus Infections Contact tracing Research Article |
| Zdroj: | BMC Public Health, Vol 20, Iss 1, Pp 1-9 (2020) BMC Public Health |
| ISSN: | 1471-2458 |
| Popis: | Background More than 2 months have passed since the novel coronavirus disease 2019 (COVID-19) first emerged in Wuhan, China. With the migration of people, the epidemic has rapidly spread within China and throughout the world. Due to the severity of the epidemic, undiscovered transmission of COVID-19 deserves further investigation. The aim of our study hypothesized possible modes of SARS-CoV-2 transmission and how the virus may have spread between two family clusters within a residential building in Guangzhou, China. Methods In a cross-sectional study, we monitored and traced confirmed patients and their close contacts from January 11 to February 5, 2020 in Guangzhou, China, including 2 family cluster cases and 61 residents within one residential building. The environmental samples of the building and the throat swabs from the patients and from their related individuals were collected for SARS-CoV-2 and tested with real-time reverse transcriptase polymerase chain reaction (RT-PCR). The relevant information was collected and reported using big data tools. Results There were two notable family cluster cases in Guangzhou, which included 3 confirmed patients (family No.1: patient A, B, C) and 2 confirmed patients (family No.2: patient D, E), respectively. None of patients had contact with other confirmed patients before the onset of symptoms, and only patient A and patient B made a short stop in Wuhan by train. Home environment inspection results showed that the door handle of family No.1 was positive of SARS-CoV-2. The close contacts of the 5 patients all tested negative of SARS-CoV-2 and in good health, and therefore were released after the official medical observation period of 14-days. Finally, according to the traceability investigation through applying big data analysis, we found an epidemiological association between family No.1 and family No.2, in which patient D (family No.2) was infected through touching an elevator button contaminated by snot with virus from patient A (family No.1) on the same day. Conclusions Contaminants with virus from confirmed patients can pollute the environment of public places, and the virus can survive on the surface of objects for a short period of time. Therefore, in addition to the conventional droplet transmission, there is also indirect contact transmission such as snot-oral transmission that plays a crucial role in community spread of the virus. |
| Databáze: | OpenAIRE |
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