The microcystic, elongated and fragmented (MELF) pattern of invasion: a single institution report of 464 consecutive FIGO grade 1 endometrial endometrioid adenocarcinomas
| Autor: | Julie A. Stephens, Floor J. Backes, David W. Cohen, Amy Joehlin-Price, David E. Cohn, Kelsey E. McHugh, Zaibo Li, Adrian A. Suarez |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty Adenoma medicine.medical_treatment Kaplan-Meier Estimate Article Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine medicine Carcinoma Humans Single institution Lymph node Aged Proportional Hazards Models Hysterectomy business.industry Proportional hazards model Middle Aged medicine.disease Endometrial Neoplasms Isolated Tumor Cells 030104 developmental biology medicine.anatomical_structure Depth of invasion 030220 oncology & carcinogenesis Lymphatic Metastasis Surgery Female Anatomy Neoplasm Grading Neoplasm Recurrence Local business Carcinoma Endometrioid |
| Popis: | MELF invasion has been associated with non-vaginal recurrences and lymph node (LN) metastases in multi-institutional case control studies, but has not been well examined in large single institution cohorts. Hysterectomy specimens with FIGO 1 endometrioid endometrial carcinoma (EEC) and lymphadenectomies from 2007 to 2012 were identified. Electronic medical records and histologic slides were reviewed. Of 464 identified cases, 163 (35.1%) were noninvasive, 60 (12.9%) had MELF, 222 (47.8%) had a component of the infiltrative invasion pattern without MELF, 13 (2.8%) had pure pushing borders of invasion, 5 (1.1%) had pure adenomyosis-like invasion, and 1 (0.2%) had pure adenoma malignum-like invasion. Sixteen cases had LN metastases. Significantly more MELF cases had positive LNs than non-MELF cases overall (18.3% vs 1.2%, p |
| Databáze: | OpenAIRE |
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