Secundum atrial septal defect is associated with reduced survival in adult men
| Autor: | Lodewijk J. Wagenaar, Berto J. Bouma, Aeilko H. Zwinderman, Teun van der Bom, Toon Oomen, Joey M. Kuijpers, Folkert J. Meijboom, Jolien W. Roos-Hesselink, Hubert W. Vliegen, Wilfred F. Heesen, A. Carla Zomer, Annelieke C.M.J. van Riel, Petronella G. Pieper, Barbara J.M. Mulder, W. Marc Waskowsky, Arie P.J. van Dijk |
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| Přispěvatelé: | Graduate School, Cardiology, Amsterdam Public Health, Epidemiology and Data Science, Amsterdam Cardiovascular Sciences, Psychiatry, Cardiovascular Centre (CVC) |
| Rok vydání: | 2015 |
| Předmět: |
PULMONARY ARTERIAL-HYPERTENSION
medicine.medical_specialty Pediatrics SEX-DIFFERENCES Heart disease Survival Epidemiology Vascular damage Radboud Institute for Health Sciences [Radboudumc 16] Population Septum secundum UNITED-STATES CHILDREN Logistic regression SDG 3 - Good Health and Well-being Internal medicine MANAGEMENT medicine education Gender disparity POPULATION education.field_of_study business.industry MORTALITY Gender medicine.disease CONGENITAL HEART-DISEASE Adult life REGISTRY Heart failure CLOSURE Cardiology Patent foramen ovale Atrial septal defect National registry Morbidity Cardiology and Cardiovascular Medicine business |
| Zdroj: | European Heart Journal, 36, 2079-2086 European heart journal, 36(31), 2079-2086. Oxford University Press European Heart Journal, 36(31), 2079-2086. Oxford University Press European Heart Journal, 36, 31, pp. 2079-2086 European Heart Journal, 36(31), 2079-2086 European Heart Journal, 36(31), 2079. Oxford University Press |
| ISSN: | 0195-668X |
| Popis: | Item does not contain fulltext AIMS: The identification of sex differences in the prognosis of adults with a secundum atrial septal defect (ASD2) could help tailor their clinical management, as it has in other cardiovascular diseases. We investigated whether disparity between the sexes exists in long-term outcome of adult ASD2 patients. METHODS AND RESULTS: Patients with ASD2 classified as the primary defect were selected from the Dutch national registry of adult congenital heart disease. Survival stratified by sex was compared with a sex-matched general population. In a total of 2207 adult patients (mean age at inclusion 44.8 years, 33.0% male), 102 deaths occurred during a cumulative follow-up of 13 584 patient-years. Median survival was 79.7 years for men and 85.6 years for women with ASD2. Compared with the age- and sex-matched general population, survival was lower for male, but equal for female patients (P = 0.015 and 0.766, respectively). Logistic regression analyses showed that men had a higher risk of conduction disturbances (OR = 1.63; 95% CI, 1.22-2.17) supraventricular dysrhythmias (OR = 1.41; 1.12-1.77), cerebrovascular thromboembolic events (OR = 1.53; 1.10-2.12), and heart failure (OR = 1.91; 1.06-3.43). CONCLUSION: In contrast to women, adult men with an ASD2 have worse survival than a sex-matched general population. Male patients also have a greater risk of morbidity during adult life. Sex disparity in survival and morbidity suggests the need for a sex-specific clinical approach towards these patients. |
| Databáze: | OpenAIRE |
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