Synthesis and herbicidal activity of novel pyrazolo[3,4-d]pyrimidin-4-one derivatives containing aryloxyphenoxypropionate moieties
| Autor: | Zhao-Jie Liu, Hong-Qing Wang, Hui Liu |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Annulation
Magnetic Resonance Spectroscopy Stereochemistry Clinical Biochemistry Pharmaceutical Science Crystallography X-Ray Biochemistry Medicinal chemistry Chemical synthesis Pyrazolopyrimidine chemistry.chemical_compound Drug Discovery Phenols Molecular Biology Tandem Molecular Structure Herbicides Organic Chemistry Biological activity General Medicine Carbon-13 NMR Pyrimidines chemistry Echinochloa X-ray crystallography Proton NMR Pyrazoles Molecular Medicine Propionates Plant Structures |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 17:2203-2209 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/j.bmcl.2007.01.083 |
| Popis: | The 6-(4-alkoxycarbonylalkoxy)phenoxy-3-alkylthio(alkylsulfonyl)-1-phenyl-5-(substituted phenyl)pyrazolo[3,4-d]pyrimidin-4-ones 6 and 7 have been synthesized via the tandem aza-Wittig and annulation reactions of the corresponding iminophosphoranes 4, aromatic isocyanates, and substituted phenols 2 in 52–98% yields. Their structures were clearly verified by spectroscopic data (IR, 1H NMR, 13C NMR, MS, and elemental analysis or X-ray diffraction crystallography). And the results of preliminary bioassay indicated that these title compounds possess potential herbicidal activity against the root of rape and barnyard grass. |
| Databáze: | OpenAIRE |
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