High-yielding 18F radiosynthesis of a novel oxytocin receptor tracer, a probe for nose-to-brain oxytocin uptake in vivo

Autor:	Edward W. Tate, Rhiannon Beard, Christophe Grundschober, Nisha Singh, Antony D. Gee
Jazyk:	angličtina
Rok vydání:	2018
Předmět:	Male 0301 basic medicine Fluorine Radioisotopes Chemistry Multidisciplinary AUTISM SPECTRUM DISORDERS VASOPRESSIN Peptide Pharmacology High yielding INTRANASAL OXYTOCIN 0302 clinical medicine Materials Chemistry chemistry.chemical_classification Radiosynthesis Metals and Alloys Brain RANDOMIZED CONTROLLED-TRIAL Olfactory Bulb 3. Good health Surfaces Coatings and Films Electronic Optical and Magnetic Materials Chemistry Receptors Oxytocin Physical Sciences Female 03 Chemical Sciences hormones hormone substitutes and hormone antagonists Half-Life medicine.drug BEHAVIORS RAT-BRAIN BINDING-SITES Peptides Cyclic Catalysis DELIVERY Heterocyclic Compounds 1-Ring Structure-Activity Relationship 03 medical and health sciences In vivo TRACER medicine Animals NASAL Rats Wistar Administration Intranasal Science & Technology Organic Chemistry General Chemistry Oxytocin receptor 030104 developmental biology chemistry Oxytocin AUTORADIOGRAPHY Positron-Emission Tomography Ceramics and Composites Nasal administration Radiopharmaceuticals 030217 neurology & neurosurgery
Zdroj:	Beard, R, Singh, N, Grundschober, C, Gee, A D & Tate, E W 2018, ' High-yielding 18F radiosynthesis of a novel oxytocin receptor tracer, a probe for nose-to-brain oxytocin uptake in vivo ', CHEMICAL COMMUNICATIONS-ROYAL SOCIETY OF CHEMISTRY, vol. 54, no. 58, pp. 8120-8123 . https://doi.org/10.1039/C8CC01400K
DOI:	10.1039/C8CC01400K
Popis:	A novel Al18F labelled peptide tracer for PET imaging of oxytocin receptor has been accessed through a high radiochemical yield approach. This tracer showed comparable affinity and higher selectivity and stability compared to oxytocin, and was used to demonstrate direct nose-to-brain uptake following intranasal administration, a common yet controversial delivery route for oxytocin-based therapeutics.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79cf1a0e2d1f9fcf9cd076cf0619ea4b https://kclpure.kcl.ac.uk/en/publications/5d02860c-0054-4963-be10-1448b4640e19 Zobrazit plný text záznamu