Long-term antipsychotic and benzodiazepine use and brain volume changes in schizophrenia: The Northern Finland Birth Cohort 1966 study

Autor: Jouko Miettunen, Jani Moilanen, Lassi Björnholm, Vesa Kiviniemi, Jussi Tohka, Pierrick Coupé, Sanna Huhtaniska, Graham K. Murray, Heli Lehtiniemi, T. Heikka, Matti Isohanni, José V. Manjón, Juha Veijola, Hannu Koponen, Erika Jääskeläinen
Přispěvatelé: Universidad Carlos III de Madrid [Madrid] (UC3M), ITACA, Universitat Politècnica de València (UPV), Laboratoire Bordelais de Recherche en Informatique (LaBRI), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS)-École Nationale Supérieure d'Électronique, Informatique et Radiocommunications de Bordeaux (ENSEIRB), Patch-based processing for medical and natural images (PICTURA), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS)-École Nationale Supérieure d'Électronique, Informatique et Radiocommunications de Bordeaux (ENSEIRB)-Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS)-École Nationale Supérieure d'Électronique, Informatique et Radiocommunications de Bordeaux (ENSEIRB), Psychiatry, Oulu University Hospital, Finnish Medicines Agency, Clinicum, Department of Psychiatry, University of Helsinki, HUS Psychiatry, A.I. Virtanen -instituutti
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Male
Pediatrics
medicine.medical_treatment
Caudate nucleus
3124 Neurology and psychiatry
Cohort Studies
Benzodiazepines
Lateral ventricles
BASAL GANGLIA
0302 clinical medicine
Basal ganglia
ORAL HALOPERIDOL
Antipsychotics
Finland
ComputingMilieux_MISCELLANEOUS
Brain
Magnetic Resonance Imaging
3. Good health
Psychiatry and Mental health
Anesthesia
Brain size
Female
Psychology
Antipsychotic Agents
MRI
Cohort study
Adult
medicine.medical_specialty
FOLLOW-UP MRI
medicine.drug_class
Neuroscience (miscellaneous)
03 medical and health sciences
MEDICATION
medicine
[INFO.INFO-IM]Computer Science [cs]/Medical Imaging
Humans
Radiology
Nuclear Medicine and imaging
Antipsychotic
Adverse effect
Benzodiazepine
NERVE GROWTH-FACTOR
3112 Neurosciences
COGNITIVE IMPAIRMENT
030227 psychiatry
FISICA APLICADA
CEREBRAL VENTRICULAR SIZE
Schizophrenia
Caudate Nucleus
MACAQUE MONKEYS
030217 neurology & neurosurgery
LONGITUDINAL MRI
CHOLINERGIC NEURONS
Zdroj: Psychiatry Research: Neuroimaging
Psychiatry Research: Neuroimaging, Elsevier, 2017, 266, pp.73-82. ⟨10.1016/j.pscychresns.2017.05.009⟩
RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
instname
ISSN: 0925-4927
1872-7506
DOI: 10.1016/j.pscychresns.2017.05.009⟩
Popis: Article
High doses of antipsychotics have been associated with loss in cortical and total gray matter in schizophrenia. However, previous imaging studies have not taken benzodiazepine use into account, in spite of evidence suggesting adverse effects such as cognitive impairment and increased mortality. In this Northern Finland Birth Cohort 1966 study, 69 controls and 38 individuals with schizophrenia underwent brain MRI at the ages of 34 and 43 years. At baseline, the average illness duration was over 10 years. Brain structures were delineated using an automated volumetry system, volBrain, and medication data on cumulative antipsychotic and benzodiazepine doses were collected using medical records and interviews. We used linear regression with intracranial volume and sex as covariates; illness severity was also taken into account. Though both medication doses associated to volumetric changes in subcortical structures, after adjusting for each other and the average PANSS total score, higher scan-interval antipsychotic dose associated only to volume increase in lateral ventricles and higher benzodiazepine dose associated with volume decrease in the caudate nucleus. To our knowledge, there are no previous studies reporting associations between benzodiazepine dose and brain structural changes. Further studies should focus on how these observations correspond to cognition and functioning.
final draft
http://purl.org/eprint/status/PeerReviewed
Databáze: OpenAIRE
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