Polycythemia vera with myelofibrosis and myeloid metaplasia. Acute hepatic failure following splenectomy
| Autor: | Raymond S. Koff, Abraham P. Zimelman, Paula A. McBrine, Aaron Miller |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Adult
Male medicine.medical_specialty Myeloid medicine.medical_treatment Splenectomy Gastroenterology Acute hepatic failure Polycythemia vera hemic and lymphatic diseases Internal medicine Metaplasia medicine Humans Myelofibrosis Polycythemia Vera business.industry General Medicine medicine.disease Extramedullary hematopoiesis Haematopoiesis medicine.anatomical_structure Primary Myelofibrosis Hepatic Encephalopathy Immunology medicine.symptom business |
| Zdroj: | American journal of clinical pathology. 74(5) |
| ISSN: | 0002-9173 |
| Popis: | Myelofibrosis with myeloid metaplasia developed during the course of polycythemia vera in a middle-aged man. Severe megakaryocytopenia and thrombocytopenia were early features of this illness and were unresponsive to splenectomy. After splenectomy, hepatic enlargement and acute hepatic failure developed. Extensive extramedullary hematopoiesis dilating hepatic sinusoids and compressing liver cells was the major pathologic finding in the liver. The mechanism of hepatic failure in this disorder is uncertain. |
| Databáze: | OpenAIRE |
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