Acupuncture attenuates repeated nicotine-induced behavioral sensitization and c-Fos expression in the nucleus accumbens and striatum of the rat
| Autor: | Dae-Hyun Hahm, Chae Ha Yang, Young Kyu Kwon, Insop Shim, Kwang-Ho Pyun, Mi Ryeo Kim, Hyejung Lee, Younbyoung Chae |
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| Rok vydání: | 2004 |
| Předmět: |
Male
Nicotine media_common.quotation_subject Acupuncture Therapy Striatum Motor Activity Pharmacology Nucleus accumbens Zusanli c-Fos Nucleus Accumbens Rats Sprague-Dawley Basal ganglia medicine Acupuncture Animals media_common biology General Neuroscience Addiction Corpus Striatum Rats Gene Expression Regulation biology.protein Psychology Proto-Oncogene Proteins c-fos Neuroscience medicine.drug |
| Zdroj: | Neuroscience Letters. 358:87-90 |
| ISSN: | 0304-3940 |
| Popis: | Repeated injections of nicotine can produce behavioral sensitization, as evidenced by an enhanced locomotor response to a subsequent injection of the drug. Behavioral sensitization has been suggested as a model for studying drug addiction. Acupuncture as a therapeutic intervention is widely used for treatment for many functional disorders, such as substance abuse and mental dysfunction. We examined the effect of acupuncture on nicotine-induced behavioral locomotor activity and c-fos expression in the nucleus accumbens and striatum utilizing the immunocytochemical detection of the Fos protein. The rats were given repeated daily nicotine injections (0.4 mg/kg s.c., twice daily for 7 days) followed by one challenging injection on the 4th day after the last daily injection. Acupuncture at zusanli (ST36), but not control, significantly attenuated expected increase in nicotine-induced locomotor activity and Fos-like-immunoreactivity in the nucleus accumebns and striatum to subsequent nicotine challenge. These findings suggest that acupuncture has a therapeutic effect on nicotine addiction, possibly by modulating postsynaptic neuronal activity in the nucleus accumbens and the striatum. |
| Databáze: | OpenAIRE |
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