Merle allele variations in the Mudi dog breed and their effects on phenotypes
| Autor: | András Gáspárdy, László Zöldág, Nóra Ninausz, Petra Zenke, Xénia Lénárt, Zsófia Pelles, László Varga |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Coat
Genotype 040301 veterinary sciences Breeding Biology 0403 veterinary science 03 medical and health sciences Dogs Animals Allele Alleles 030304 developmental biology Genetics 0303 health sciences General Veterinary Pigmentation Homozygote Genetic Variation Pigment cells 04 agricultural and veterinary sciences Phenotype Breed Mutation Sample collection gp100 Melanoma Antigen |
| Zdroj: | Acta Veterinaria Hungarica. 67:159-173 |
| ISSN: | 1588-2705 0236-6290 |
| Popis: | A retrotransposon insertion in the SILV gene is associated with a peculiar phenotype of dog, known as a merle. It is characterised by various areas of their coat colour becoming diluted due to a malfunction in the eumelanin-producing pigment cells. Recent studies have shown that the exact size of the short interspersed element (SINE) insertion is in correlation with specific phenotypic attributes, but was not able to absolutely confine dogs to a certain colour pattern. Our study focused on the merle variations occurring in the Mudi breed. Altogether, 123 dog samples from 11 countries were tested and genotyped. The exact length of the merle alleles were determined by automated fluorescent capillary fragment analysis. The most frequent merle genotype in this Mudi sample collection was the ‘classic’ merle (m/M: 61.8%), whereas other variants, such as atypical (m/Ma and m/Ma+: 5.7%), harlequin (m/Mh: 13.8%), double merle (M/M: 0.8%) and mosaic profiles (17.9%) were also observed. The practical significance of testing this mutation is that, phenotypically, not only merle dogs are carriers of this insertion, but also the so-called hidden merle individuals (where the merle phenotype is fully covered by the pheomelanin-dominated colouration) are potentially capable of producing unintentionally homozygous ‘double merle’ progeny with ophthalmologic, viability and auditory impairments. |
| Databáze: | OpenAIRE |
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