Update on the search for DNA markers linked to manic-depressive illness in the old order amish
| Autor: | David L. Pauls, Tim Keith, Cleona R. Allen, Kathleen M. Falls, Edward I. Ginns, Steven M. Paul, Janice A. Egeland |
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| Rok vydání: | 1992 |
| Předmět: |
Genetic Markers
Male Bipolar Disorder Genetic Linkage Genome Cell Line Centimorgan Gene mapping Genetic linkage Ethnicity medicine Humans Bipolar disorder Biological Psychiatry Genetics Linkage (software) Models Genetic Chromosome Mapping medicine.disease Psychiatry and Mental health Phenotype Genetic marker Old Order Amish Female Psychology Polymorphism Restriction Fragment Length |
| Zdroj: | Journal of Psychiatric Research. 26:305-308 |
| ISSN: | 0022-3956 |
| Popis: | In this report we describe our efforts to identify a gene involved in bipolar illness using a large, multigenerational Old Order Amish pedigree with many affected individuals. The original collection of cell lines from Amish pedigree 110 has been extended to include 169 individuals. We have used over 250 markers spaced at approximately 20 centiMorgans that detect restriction length fragment polymorphisms, but no LOD scores greater than 3 have been obtained from pairwise linkage analyses. We are expanding our collection of cell lines from both normal and affected family members and updating our diagnostic data as we continue our systematic screening of the genome for a gene involved in bipolar illness. |
| Databáze: | OpenAIRE |
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