Genetic mapping in the region of the mouse X-inactivation center
| Autor: | Neil Brockdorff, Renata M.J. Hamvas, J. T. Keer, Stephen D.M. Brown, David C. Page, Sohaila Rastan |
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| Rok vydání: | 1990 |
| Předmět: |
Genetics
X Chromosome biology Mus spretus Breakpoint Chromosome Mapping Locus (genetics) biology.organism_classification Genetic analysis X-inactivation Muridae Blotting Southern Gene mapping Dosage Compensation Genetic Animals Gene Crosses Genetic Polymorphism Restriction Fragment Length X chromosome |
| Zdroj: | Genomics. 7:566-572 |
| ISSN: | 0888-7543 |
| DOI: | 10.1016/0888-7543(90)90200-e |
| Popis: | The mouse X-inactivation center lies just distal to the T16H breakpoint. Utilizing pedigree analysis of backcross progeny from a Mus domesticus/Mus spretus interspecific cross, we have mapped a number of genetic loci, gene probes, microclones, and EagI linking clones distal to the T16H breakpoint. The genetic analysis provides a detailed genetic map in the vicinity of the mouse X-inactivation center. Comparative mapping data from the human X chromosome indicate that the most probable location of the mouse X-inactivation center is distal to Ccg-1 and in the region of the Pgk-1 locus. We report the assignment of two new loci, EM13 and DXSmh44, to the Ccg-1 Pgk-1 interval. |
| Databáze: | OpenAIRE |
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