Stereotactic Radiotherapy in the Treatment of Paraneoplastic Vasculitis in Oligometastatic Renal Cell Carcinoma
| Autor: | Alan Liang Zhou, Delvina Hasimja Saraqini, James Watterson, Laura Burgess, Christopher Morash, Jeff Yao, Samuel Martin, Kiefer Lypka, Robert MacRae, Marissa Keenan, Christina Canil |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Constitutional symptoms 030232 urology & nephrology Case Report paraneoplastic syndrome urologic and male genital diseases 03 medical and health sciences 0302 clinical medicine renal cell carcinoma (RCC) Renal cell carcinoma medicine Chondritis RC254-282 Palpable purpura business.industry Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease stereotactic radiotherapy (SBRT) oligometastases female genital diseases and pregnancy complications 030220 oncology & carcinogenesis Polyarthritis Radiology medicine.symptom business Vasculitis paraneoplastic vasculitis Scleritis Systemic vasculitis |
| Zdroj: | Current Oncology Current Oncology, Vol 28, Iss 162, Pp 1744-1750 (2021) |
| ISSN: | 1718-7729 |
| DOI: | 10.3390/curroncol28030162 |
| Popis: | Approximately 20% of renal cell carcinoma (RCC) is diagnosed because of paraneoplastic manifestations. RCC has been associated with a large variety of paraneoplastic syndromes (PNS), but it is rarely associated with PNS vasculitis. We present a case of a previously healthy male who presented with systemic vasculitis; bitemporal headaches, diplopia, polyarthritis, palpable purpura, tongue lesion, peri-orbital edema, scleritis, chondritis and constitutional symptoms. He was subsequently found to have oligometastatic RCC. Both his primary lesion and site of oligometastasis were treated with stereotactic radiotherapy (SBRT) and resulted in the resolution of his vasculitis, as well as sustained oncologic response. This is the first case to demonstrate that effective sustained treatment for PNS vasculitis due to oligometastatic RCC is possible with SBRT. |
| Databáze: | OpenAIRE |
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