Mesenchymal Stem Cell (MSC)-Derived Extracellular Vesicles: Potential Therapeutics as MSC Trophic Mediators in Regenerative Medicine
| Autor: | Yin‐gang Zhang, Qi‐ling Yuan, Qian Chen |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Histology Biology Regenerative Medicine Regenerative medicine Article 03 medical and health sciences Extracellular Vesicles 0302 clinical medicine Animals Humans Secretion Progenitor cell Ecology Evolution Behavior and Systematics Mesenchymal stem cell RNA Cell Differentiation Mesenchymal Stem Cells Non-coding RNA Microvesicles Cell biology Disease Models Animal 030104 developmental biology Anatomy 030217 neurology & neurosurgery Intracellular Biotechnology |
| Zdroj: | Anat Rec (Hoboken) |
| ISSN: | 1932-8494 |
| Popis: | Mesenchymal stem cells (MSCs) are pluripotent progenitor cells with the capabilities of self-renewing, differentiating into multiple lineages, and achieving trophic effects during tissue repair. MSCs can secrete extracellular vesicles (EVs) including exosomes and microvesicles, which mediate their trophic effects on other cells. Carrying a variety of intracellular molecules of MSCs including lipids, proteins, RNA (mRNA and noncoding RNA), and DNA, EVs deliver them into other cells to regulate tissue regeneration process. The therapeutic effects of MSC-derived EVs have been observed in a number of animal disease models. In this review, we focus on the current state and future directions of MSC-derived EVs in regenerative medicine. Anat Rec, 2019. © 2019 Wiley Periodicals, Inc. |
| Databáze: | OpenAIRE |
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